Recent Advances in Costimulatory Blockade to Induce Immune Tolerance in Liver Transplantation

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Mar 18

PMID 33732228

Citations 4

Authors

Mingjie Ding

Yuting He

Shuijun Zhang

Wenzhi Guo

Affiliations

Soon will be listed here.

Abstract

Liver transplantation is an effective therapy for end-stage liver disease. However, most postoperative patients must take immunosuppressive drugs to prevent organ rejection. Interestingly, some transplant recipients have normal liver function and do not experience organ rejection after the withdrawal of immunosuppressive agents. This phenomenon, called immune tolerance, is the ultimate goal in clinical transplantation. Costimulatory molecules play important roles in T cell-mediated immune responses and the maintenance of T cell tolerance. Blocking costimulatory pathways can alter T cell responses and prolong graft survival. Better understanding of the roles of costimulatory molecules has facilitated the use of costimulatory blockade to effectively induce immune tolerance in animal transplantation models. In this article, we review the state of the art in costimulatory pathway blockade for the induction of immune tolerance in transplantation and its potential application prospects for liver transplantation.

Citing Articles

Immunology demystified: A guide for transplant hepatologists.

Kosuta I, Kelava T, Ostojic A, Sesa V, Mrzljak A, Lalic H World J Transplant. 2024; 14(1):89772.

PMID: 38576757 PMC: 10989464. DOI: 10.5500/wjt.v14.i1.89772.

Exploring Costimulatory Blockade-Based Immunologic Strategies in Transplantation: Are They a Promising Immunomodulatory Approach for Organ and Vascularized Composite Allotransplantation?.

Grosu-Bularda A, Hodea F, Zamfirescu D, Stoian A, Teodoreanu R, Lascar I J Pers Med. 2024; 14(3).

PMID: 38541064 PMC: 10971463. DOI: 10.3390/jpm14030322.

Immune Responses to Anti-Hepatitis C Virus Antibodies during Pre-Liver Transplantation Direct-Acting Antiviral Therapy in Hepatitis C Virus-Infected Recipients Associated with Post-Liver Transplantation Allograft Injury.

Lin S, Wu K, Wang C, Huang K, Hsu L, Eng H Antibodies (Basel). 2024; 13(1).

PMID: 38247571 PMC: 10801541. DOI: 10.3390/antib13010007.

Transcriptomic analysis of graft liver provides insight into the immune response of rat liver transplantation.

Cao W, Lu J, Li S, Song F, Xu J Front Immunol. 2022; 13:947437.

PMID: 36426354 PMC: 9680555. DOI: 10.3389/fimmu.2022.947437.

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