C-Phycocyanin-a Novel Protein from - Toxicity, Antioxidant and Immunomodulatory Studies

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2021 Mar 18

PMID 33732072

Citations 26

Authors

Priyanka Grover

Aseem Bhatnagar

Neeraj Kumari

Ananth Narayan Bhatt

Dhruv Kumar Nishad

Jubilee Purkayastha

Affiliations

Soon will be listed here.

Abstract

A pigment-protein highly dominant in Spirulina is known as C-Phycocyanin. Earlier, studies has shown that C-phycocyanin is having many biological activities like antioxidant and anti-inflammatory activities, antiplatelet, hepatoprotective, and cholesterol-lowering properties. Interestingly, there are scanty experimental findings on the immunomodulatory and antioxidant effects of C-phycocyanin. This work is aimed at evaluation of the effects of C-phycocyanin on immunomodulation and antioxidant potential in Balb/c mice. Our results of toxicity, immunomodulatory and antioxidant effects of C-Phycocyanin suggests that C-phycocyanin is very safe for consumption and having substantial antioxidant potential and also possess immunomodulatory activities in Balb/c mice in a dosage dependent manner. C-phycocyanin doesn't cause acute and subacute toxicity in the animal model (male, Balb/c mice) studied. We have reported that C-phycocyanin exhibited immunomodulation performance in this animal model.

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References

Scott M, Lubin B, Zuo L, Kuypers F . Erythrocyte defense against hydrogen peroxide: preeminent importance of catalase. J Lab Clin Med. 1991; 118(1):7-16. View

Finamore A, Palmery M, Bensehaila S, Peluso I . Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and Ecofriendly . Oxid Med Cell Longev. 2017; 2017:3247528. PMC: 5274660. DOI: 10.1155/2017/3247528. View

Torres-Duran P, Ferreira-Hermosillo A, Juarez-Oropeza M . Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary report. Lipids Health Dis. 2007; 6:33. PMC: 2211748. DOI: 10.1186/1476-511X-6-33. View

Peluso I, Romanelli L, Palmery M . Interactions between prebiotics, probiotics, polyunsaturated fatty acids and polyphenols: diet or supplementation for metabolic syndrome prevention?. Int J Food Sci Nutr. 2014; 65(3):259-67. DOI: 10.3109/09637486.2014.880670. View

Zulkawi N, Ng K, Zamberi R, Yeap S, Satharasinghe D, Jaganath I . In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods; Xeniji™. BMC Complement Altern Med. 2017; 17(1):344. PMC: 5493119. DOI: 10.1186/s12906-017-1845-6. View

Netea M, van der Meer J, van Deuren M, Kullberg B . Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing?. Trends Immunol. 2003; 24(5):254-8. DOI: 10.1016/s1471-4906(03)00079-6. View

Ores J, Campos Assumpcao de Amarante M, Kalil S . Co-production of carbonic anhydrase and phycobiliproteins by Spirulina sp. and Synechococcus nidulans. Bioresour Technol. 2016; 219:219-227. DOI: 10.1016/j.biortech.2016.07.133. View

Li B, Chu X, Gao M, Li W . Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin. Acta Biochim Biophys Sin (Shanghai). 2010; 42(1):80-9. DOI: 10.1093/abbs/gmp104. View

Bowdish D, Loffredo M, Mukhopadhyay S, Mantovani A, Gordon S . Macrophage receptors implicated in the "adaptive" form of innate immunity. Microbes Infect. 2007; 9(14-15):1680-7. DOI: 10.1016/j.micinf.2007.09.002. View

10.

Ichimura M, Kato S, Tsuneyama K, Matsutake S, Kamogawa M, Hirao E . Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome. Nutr Res. 2013; 33(5):397-405. DOI: 10.1016/j.nutres.2013.03.006. View

11.

Dundarz M, Turkbay T, Akay C, Sarici S, Aydin A, Denli M . Antioxidant enzymes and lipid peroxidation in adolescents with inhalant abuse. Turk J Pediatr. 2003; 45(1):43-5. View

12.

Romay C, Armesto J, Remirez D, Gonzalez R, Ledon N, Garcia I . Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae. Inflamm Res. 1998; 47(1):36-41. DOI: 10.1007/s000110050256. View

13.

Romay C, Ledon N, Gonzalez R . Effects of phycocyanin extract on prostaglandin E2 levels in mouse ear inflammation test. Arzneimittelforschung. 2001; 50(12):1106-9. DOI: 10.1055/s-0031-1300340. View

14.

Lee S, Ra J, Song J, Gwak C, Kwon H, Yim S . Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model. J Ethnopharmacol. 2010; 133(3):973-9. DOI: 10.1016/j.jep.2010.07.018. View

15.

Werneck M, Lugo-Villarino G, Hwang E, Cantor H, Glimcher L . T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008; 180(12):8004-10. PMC: 3709580. DOI: 10.4049/jimmunol.180.12.8004. View

16.

Bahrami S, Shahriari A, Tavalla M, Azadmanesh S, Hamidinejat H . Blood Levels of Oxidant/Antioxidant Parameters in Rats Infected with . Oxid Med Cell Longev. 2016; 2016:8045969. PMC: 5056297. DOI: 10.1155/2016/8045969. View

17.

Pang X, Panee J . Roles of glutathione in antioxidant defense, inflammation, and neuron differentiation in the thalamus of HIV-1 transgenic rats. J Neuroimmune Pharmacol. 2014; 9(3):413-23. PMC: 4868348. DOI: 10.1007/s11481-014-9538-0. View

18.

Park S, Park G, Ko W, Kim Y . Dichroa febrifuga Lour. inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB, MAPK and Akt activation in macrophages. J Ethnopharmacol. 2009; 125(2):246-51. DOI: 10.1016/j.jep.2009.07.003. View

19.

Eriksen N . Production of phycocyanin--a pigment with applications in biology, biotechnology, foods and medicine. Appl Microbiol Biotechnol. 2008; 80(1):1-14. DOI: 10.1007/s00253-008-1542-y. View

20.

Adams D, Hamilton T . The cell biology of macrophage activation. Annu Rev Immunol. 1984; 2:283-318. DOI: 10.1146/annurev.iy.02.040184.001435. View