LncRNA Promotes Clear Cell Renal Cell Carcinoma Progression by Targeting to Upregulate

Overview

Journal Cancer Manag Res

Publisher Dove Medical Press

Specialty Oncology

Date 2021 Mar 18

PMID 33732021

Citations 14

Authors

Yu Yang

Pengfeng Gong

Dongwei Yao

Dong Xue

Xiaozhou He

Affiliations

Soon will be listed here.

Abstract

Background: Long noncoding RNAs (lncRNAs) have been regarded as crucial regulators in many cancers, including clear cell renal cell carcinoma (ccRCC). This research aimed to explore the biological role and molecular mechanism of lncRNA in ccRCC.

Materials And Methods: The expression levels of and were examined by RT-qPCR. Cell viability, migration and invasion were examined by CCK-8 and transwell assays. Luciferase reporter and RIP assays were adopted to verify the interaction between and or .

Results: It was found that expression was highly expressed in ccRCC tissues and cells, and patients with high expression of had a short overall survival time. Moreover, depletion attenuated ccRCC cell viability, migration and invasion. In addition, was confirmed as a downstream target of and was inversely regulated by , and was a target of . Functional assays demonstrated that silencing or addition abolished the inhibitory effects of knockdown on ccRCC progression.

Conclusion: The results of the present study indicated that accelerated the development and progression of ccRCC by upregulating via sponging , suggesting a potential therapeutic target for patients with ccRCC.

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