Efficacy of Dorsal Root Ganglion Pulsed Radiofrequency Combined with Paravertebral Injection of Recombinant Human Interferon-α2b in Herpetic Neuralgia

Overview

Journal J Pain Res

Publisher Dove Medical Press

Date 2021 Mar 18

PMID 33732017

Citations 9

Authors

Yong Fei

Bing Huang

Jiajia Deng

Longsheng Xu

Ming Yao

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this study was to investigate the clinical efficacy of dorsal root ganglion (DRG) pulsed radiofrequency combined with paravertebral injection of recombinant human interferon-α2b in the treatment of patients with acute herpes zoster neuralgia and its preventive effectiveness on postherpetic neuralgia (PHN).

Methods: A retrospective analysis of 62 patients with acute herpes zoster neuralgia was implemented. All patients were divided into two groups: pulsed radiofrequency paraspinal injection of recombinant human interferon-α2b (group P); pulsed radiofrequency combined with paravertebral injection of saline (group C). The numerical rating scales (NRS) scores were used for pain assessment, and the dose of the analgesic drug was recorded. Gal-3 and IL-6 levels in blood were compared between the two groups before treatment and at 1 week, 2, and 4 weeks after treatment. The incidence of PHN was recorded in both groups.

Results: The pain intensity, the levels of Gal-3 and IL-6 in blood and the dose of oral administration of gabapentin capsules and morphine were reduced in all patients after treatment. Compared with group C, patients in group P had lower NRS scores, blood levels of Gal-3 and IL-6, and dosages of oral gabapentin capsules and morphine hydrochloride immediate-release tablets after treatment. The incidence of PHN was significantly lower at 8 and 12 weeks.

Conclusion: DRG pulsed radiofrequency combined with paravertebral injection of recombinant human interferon-α2b for acute stage herpes zoster neuralgia is a more effective treatment, and can effectively prevent the incidence rate of PHN.

Citing Articles

Efficacy and Safety of Pulsed Radiofrequency of Dorsal Root Ganglion in Elderly Patient Population With Acute and Subacute Zoster-Related Pain.

Dagistan G, Erdine S Pain Res Manag. 2024; 2024:6586167.

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Identifying and Evaluating Biological Markers of Postherpetic Neuralgia: A Comprehensive Review.

Li Y, Jin J, Kang X, Feng Z Pain Ther. 2024; 13(5):1095-1117.

PMID: 39126594 PMC: 11393369. DOI: 10.1007/s40122-024-00640-3.

Outcomes of Twice Repeated High-Voltage Long-Duration Pulsed Radiofrequency Treatment in Subacute Postherpetic Neuralgia: a Retrospective Single-Center Analysis.

Wen H, Wang Y, Cheng H, Wang B, Hu X J Pain Res. 2024; 17:2043-2050.

PMID: 38881760 PMC: 11179646. DOI: 10.2147/JPR.S465251.

Comparing the efficacy and safety of high-voltage and standard-voltage pulsed radiofrequency for the treatment of postherpetic neuralgia: A pooled analysis from randomized controlled trials.

Cai S, Du L, Xiang X, Liu C, Zhang Y, Peng Z Heliyon. 2024; 10(9):e30525.

PMID: 38765102 PMC: 11101789. DOI: 10.1016/j.heliyon.2024.e30525.

Progress in Radiofrequency Therapy for Zoster-Associated Pain About Parameters, Modes, Targets, and Combined Therapy: A Narrative Review.

Rui M, Ni H, Xie K, Xu L, Yao M Pain Ther. 2023; 13(1):23-32.

PMID: 37962817 PMC: 10796860. DOI: 10.1007/s40122-023-00561-7.

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