Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2021 Mar 18

PMID 33731986

Citations 2

Authors

Ghulam Sarwar Khalid

Mohammad Hassan Hamrah

Elaha Somaya Ghafary

Sepideh Hosseini

Fateme Almasi

Affiliations

Soon will be listed here.

Abstract

Background: Xanthorrhizol is one of the numerous phytochemicals whose pharmacological benefits have been explored for its antibacterial and antimicrobial effects. In light of the role bacteria play for initiating tooth decay, this present systematic review assessed xanthorrhizol's effect against dental caries.

Methods: The electronic databases including Pubmed, Scopus and Embase were searched up to September 2020, Studies examining the antibacterial and antimicrobial effects of xanthorrhizol in the prevention and treatment of dental caries.

Results: Eleven studies met the criteria for final inclusion. Findings from these studies showed that xanthorrhizol showed significant inhibition of notable caries causing bacteria including , , and . Furthermore, there was no reported toxicity. However, it could not selectively target the growth of cariogenic bacteria.

Conclusion: So far, studies exploring the use of xanthorrhizol as a potential drug for the prevention and treatment of dental caries have shown promising outcomes. However, more work needs to be done especially in areas such as optimal dose or concentration, in addition, in vitro, in vivo and clinical studies and selective targeting of cariogenic bacteria has been performed.

Citing Articles

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The antimicrobial and antibiofilm effects of three herbal extracts on compared with Chlorhexidine 0.2% ( study).

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References

Rimpler H, Hansel R, Kochendoerfer L . [Xanthorrhizol, a new sesquiterpene from Curcuma xanthorrhiza]. Z Naturforsch B. 1970; 25(9):995-8. View

Kim J, Kim H, Hwang J, Lee H, Kwon H, Kim B . Antibacterial characteristics of Curcuma xanthorrhiza extract on Streptococcus mutans biofilm. J Microbiol. 2008; 46(2):228-32. DOI: 10.1007/s12275-007-0167-7. View

Sogi S, Subbareddy V, Kiran S . Contamination of toothbrush at different time intervals and effectiveness of various disinfecting solutions in reducing the contamination of toothbrush. J Indian Soc Pedod Prev Dent. 2002; 20(3):81-5. View

Lee L, Shim J, Rukayadi Y, Hwang J . Antibacterial activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. against foodborne pathogens. J Food Prot. 2008; 71(9):1926-30. DOI: 10.4315/0362-028x-71.9.1926. View

Oon S, Nallappan M, Tee T, Shohaimi S, Kassim N, Saariwijaya M . Xanthorrhizol: a review of its pharmacological activities and anticancer properties. Cancer Cell Int. 2015; 15:100. PMC: 4618344. DOI: 10.1186/s12935-015-0255-4. View

Mah T . Biofilm-specific antibiotic resistance. Future Microbiol. 2012; 7(9):1061-72. DOI: 10.2217/fmb.12.76. View

Hwang J, Shim J, Pyun Y . Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens. Fitoterapia. 2000; 71(3):321-3. DOI: 10.1016/s0367-326x(99)00170-7. View

Freires I, Denny C, Benso B, de Alencar S, Rosalen P . Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review. Molecules. 2015; 20(4):7329-58. PMC: 6272492. DOI: 10.3390/molecules20047329. View

Philip N, Leishman S, Bandara H, Walsh L . Growth Inhibitory Effects of Antimicrobial Natural Products against Cariogenic and Health-Associated Oral Bacterial Species. Oral Health Prev Dent. 2020; 18(3):537-542. PMC: 11654489. DOI: 10.3290/j.ohpd.a44307. View

10.

Rukayadi Y, Hwang J . In vitro activity of xanthorrhizol isolated from the rhizome of Javanese turmeric (Curcuma xanthorrhiza Roxb.) against Candida albicans biofilms. Phytother Res. 2012; 27(7):1061-6. DOI: 10.1002/ptr.4834. View

11.

Dong L, Tong Z, Linghu D, Lin Y, Tao R, Liu J . Effects of sub-minimum inhibitory concentrations of antimicrobial agents on Streptococcus mutans biofilm formation. Int J Antimicrob Agents. 2012; 39(5):390-5. DOI: 10.1016/j.ijantimicag.2012.01.009. View

12.

Palombo E . Traditional Medicinal Plant Extracts and Natural Products with Activity against Oral Bacteria: Potential Application in the Prevention and Treatment of Oral Diseases. Evid Based Complement Alternat Med. 2009; 2011:680354. PMC: 3145422. DOI: 10.1093/ecam/nep067. View

13.

Selwitz R, Ismail A, Pitts N . Dental caries. Lancet. 2007; 369(9555):51-9. DOI: 10.1016/S0140-6736(07)60031-2. View

14.

Kouidhi B, Al Qurashi Y, Chaieb K . Drug resistance of bacterial dental biofilm and the potential use of natural compounds as alternative for prevention and treatment. Microb Pathog. 2015; 80:39-49. DOI: 10.1016/j.micpath.2015.02.007. View

15.

Yang L, Liu Y, Wu H, Hoiby N, Molin S, Song Z . Current understanding of multi-species biofilms. Int J Oral Sci. 2011; 3(2):74-81. PMC: 3469880. DOI: 10.4248/IJOS11027. View

16.

Lim C, Jin D, Mok H, Oh S, Lee J, Hwang J . Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. J Neurosci Res. 2005; 82(6):831-8. DOI: 10.1002/jnr.20692. View

17.

Fernando S, Tadakamadla S, Bakr M, Scuffham P, Johnson N . Indicators of Risk for Dental Caries in Children: A Holistic Approach. JDR Clin Trans Res. 2019; 4(4):333-341. DOI: 10.1177/2380084419834236. View

18.

Wolcott R, Costerton J, Raoult D, Cutler S . The polymicrobial nature of biofilm infection. Clin Microbiol Infect. 2012; 19(2):107-12. DOI: 10.1111/j.1469-0691.2012.04001.x. View

19.

Barad M, Ishnava K, Chauhan J . Anticariogenic activity and phytochemical studies of crude extract from some Indian plant leaves. J Intercult Ethnopharmacol. 2015; 3(2):85-90. PMC: 4576798. DOI: 10.5455/jice.20140228010459. View

20.

Hoiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O . Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents. 2010; 35(4):322-32. DOI: 10.1016/j.ijantimicag.2009.12.011. View