AGREEMENT BETWEEN CLINICAL AND ANATOMOPATHOLOGICAL DIAGNOSES IN PEDIATRIC INTENSIVE CARE

Overview

Journal Rev Paul Pediatr

Specialty Pediatrics

Date 2021 Mar 17

PMID 33729321

Citations 4

Authors

Fernanda Staub Rodrigues

Isabella Correa DE Oliveira

Monica Nunes Lima Cat

Maria Clara Lopes Mattos

Gabriela Andrioli Silva

Affiliations

Soon will be listed here.

Abstract

Objective: Although autopsy is deemed the gold standard for diagnosis, its performance has been decreasing while adverse events have been increasing, of which 17% consist in diagnostic errors. The purpose of this study was to estimate the prevalence of diagnostic errors based on anatomopathological diagnosis in a Pediatric Intensive Care Unit (PICU).

Methods: This is a cross-sectional, retrospective study on 31patients who died between 2004 and 2014. Diagnoses were compared in order to assess whether there was agreement between clinical major diagnosis (CMD) and the cause of death as described in the autopsy record (CDAR), which were classified according to the Goldman Criteria.

Results: Of 3,117 patients, 263 died (8.4%). Autopsy was conducted in 38 cases (14.4%), and 31 were included in the study. Therewas a 67% decrease in the number of autopsies over the last 10years. Absolute agreement between the diagnoses (class V) was observed in 18 cases (58.0%), and disagreement (class I), in 11 (35.4%). Therewas greater difficulty in diagnosing acute diseases and diseases of rapid fatal evolution such as myocarditis. Sevenpatients were admitted in critical health conditions and died within the first 24 hours of hospitalization.

Conclusions: Autopsy not only enables to identify diagnostic errors, but also provides the opportunity to learn from mistakes. The results emphasize the relevance of the autopsy examination for diagnostic elucidation and the creation of an information database concerning the main diagnoses of patients who rapidly progress to death in PICU, increasing the index of clinical suspicion of the team working at this unit.

Citing Articles

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How often are heart diseases correctly diagnosed antemortem in children with fatal illnesses? A retrospective review of medical and autopsy records.

Karande S, Vaideeswar P, More T J Postgrad Med. 2023; 69(4):224-226.

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Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years.

Ribeiro M, Duarte-Neto A, Dolhnikoff M, Lindoso L, Lourenco B, Marques H Clinics (Sao Paulo). 2023; 78:100184.

PMID: 36972631 PMC: 10091384. DOI: 10.1016/j.clinsp.2023.100184.

Diagnostic error in the pediatric hospital: a narrative review.

Sawicki J, Nystrom D, Purtell R, Good B, Chaulk D Hosp Pract (1995). 2021; 49(sup1):437-444.

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