Antidiarrheal Effect of Vogel (Leguminosae) on Mice Involves Adrenergic Pathway Activation

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2021 Mar 17

PMID 33727938

Authors

Filipe R M B Oliveira

Sarah R D Ferreira

Giulyane T Aires-Moreno

Anne D S Silva

Yuri M Nascimento

Vicente C O Costa

Josean F Tavares

Marcelo S Silva

Fabiana A Cavalcante

Affiliations

Soon will be listed here.

Abstract

Several secondary metabolites have been isolated from (Leguminosae), mainly flavonoids. These compounds are known for many pharmacological actions, such as antispasmodic and antidiarrheal. Therefore, we evaluated the antidiarrheal effect of the ethanolic extract obtained from aerial parts (ZB-EtOH), as well as its underlying mechanisms. Castor-oil-induced diarrhea, fluid accumulation, and intestinal transit (normal and castor oil induced) were performed to assess the antidiarrheal, antisecretory, and antipropulsive activities of the extract. The involvement of opioid and adrenergic pathways was also investigated. ZB-EtOH inhibited, in a dose-dependent manner, both total defecation frequency and the number of watery stools. The extract showed no effect on fluid accumulation or normal intestinal transit. On the other hand, when the animals were pretreated with castor oil, the extract decreased the distance traveled by the marker in the small intestine. Investigation of the involvement of opioid and adrenergic systems showed that the pharmacological potency of the extract did not change in the presence of naloxone, but it was reduced in the presence of yohimbine. The data indicate that has an antidiarrheal effect due to inhibition of the intestinal motility through adrenergic pathway activation.

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