Medial Prefrontal Cortex and Hippocampal Activity Differentially Contribute to Ordinal and Temporal Context Retrieval During Sequence Memory

Overview

Journal Learn Mem

Specialty Neurology

Date 2021 Mar 16

PMID 33723033

Citations 6

Authors

Puck C Reeders

Amanda G Hamm

Timothy A Allen

Aaron T Mattfeld

Affiliations

Soon will be listed here.

Abstract

Remembering sequences of events defines episodic memory, but retrieval can be driven by both ordinality and temporal contexts. Whether these modes of retrieval operate at the same time or not remains unclear. Theoretically, medial prefrontal cortex (mPFC) confers ordinality, while the hippocampus (HC) associates events in gradually changing temporal contexts. Here, we looked for evidence of each with BOLD fMRI in a sequence task that taxes both retrieval modes. To test ordinal modes, items were transferred between sequences but retained their position (e.g., AB). Ordinal modes activated mPFC, but not HC. To test temporal contexts, we examined items that skipped ahead across lag distances (e.g., AB). HC, but not mPFC, tracked temporal contexts. There was a mPFC and HC by retrieval mode interaction. These current results suggest that the mPFC and HC are concurrently engaged in different retrieval modes in support of remembering when an event occurred.

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References

Mankin E, Sparks F, Slayyeh B, Sutherland R, Leutgeb S, Leutgeb J . Neuronal code for extended time in the hippocampus. Proc Natl Acad Sci U S A. 2012; 109(47):19462-7. PMC: 3511087. DOI: 10.1073/pnas.1214107109. View

Orlov T, Yakovlev V, Amit D, Hochstein S, Zohary E . Serial memory strategies in macaque monkeys: behavioral and theoretical aspects. Cereb Cortex. 2002; 12(3):306-17. DOI: 10.1093/cercor/12.3.306. View

Tiganj Z, Jung M, Kim J, Howard M . Sequential Firing Codes for Time in Rodent Medial Prefrontal Cortex. Cereb Cortex. 2017; 27(12):5663-5671. PMC: 6433183. DOI: 10.1093/cercor/bhw336. View

Orlov T, Yakovlev V, Hochstein S, Zohary E . Macaque monkeys categorize images by their ordinal number. Nature. 2000; 404(6773):77-80. DOI: 10.1038/35003571. View

Avants B, Epstein C, Grossman M, Gee J . Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med Image Anal. 2007; 12(1):26-41. PMC: 2276735. DOI: 10.1016/j.media.2007.06.004. View

Polyn S, Kahana M . Memory search and the neural representation of context. Trends Cogn Sci. 2007; 12(1):24-30. PMC: 2839453. DOI: 10.1016/j.tics.2007.10.010. View

Mau W, Sullivan D, Kinsky N, Hasselmo M, Howard M, Eichenbaum H . The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales. Curr Biol. 2018; 28(10):1499-1508.e4. PMC: 5964012. DOI: 10.1016/j.cub.2018.03.051. View

Eichenbaum H, Yonelinas A, Ranganath C . The medial temporal lobe and recognition memory. Annu Rev Neurosci. 2007; 30:123-52. PMC: 2064941. DOI: 10.1146/annurev.neuro.30.051606.094328. View

Ross R, Brown T, Stern C . The retrieval of learned sequences engages the hippocampus: Evidence from fMRI. Hippocampus. 2009; 19(9):790-9. PMC: 2922924. DOI: 10.1002/hipo.20558. View

10.

Dolleman-van der Weel M, Griffin A, Ito H, Shapiro M, Witter M, Vertes R . The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior. Learn Mem. 2019; 26(7):191-205. PMC: 6581009. DOI: 10.1101/lm.048389.118. View

11.

Maloney L, Zhang H . Decision-theoretic models of visual perception and action. Vision Res. 2010; 50(23):2362-74. DOI: 10.1016/j.visres.2010.09.031. View

12.

Howard M, Fotedar M, Datey A, Hasselmo M . The temporal context model in spatial navigation and relational learning: toward a common explanation of medial temporal lobe function across domains. Psychol Rev. 2005; 112(1):75-116. PMC: 1421376. DOI: 10.1037/0033-295X.112.1.75. View

13.

Milner B, Petrides M, Smith M . Frontal lobes and the temporal organization of memory. Hum Neurobiol. 1985; 4(3):137-42. View

14.

Eichenbaum H . On the Integration of Space, Time, and Memory. Neuron. 2017; 95(5):1007-1018. PMC: 5662113. DOI: 10.1016/j.neuron.2017.06.036. View

15.

Allen T, Fortin N . The evolution of episodic memory. Proc Natl Acad Sci U S A. 2013; 110 Suppl 2:10379-86. PMC: 3690604. DOI: 10.1073/pnas.1301199110. View

16.

Gorgolewski K, Burns C, Madison C, Clark D, Halchenko Y, Waskom M . Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python. Front Neuroinform. 2011; 5:13. PMC: 3159964. DOI: 10.3389/fninf.2011.00013. View

17.

Benoit R, Gilbert S, Frith C, Burgess P . Rostral prefrontal cortex and the focus of attention in prospective memory. Cereb Cortex. 2011; 22(8):1876-86. PMC: 3388891. DOI: 10.1093/cercor/bhr264. View

18.

Goyal A, Miller J, Watrous A, Lee S, Coffey T, Sperling M . Electrical Stimulation in Hippocampus and Entorhinal Cortex Impairs Spatial and Temporal Memory. J Neurosci. 2018; 38(19):4471-4481. PMC: 5943975. DOI: 10.1523/JNEUROSCI.3049-17.2018. View

19.

Allen T, Salz D, Mckenzie S, Fortin N . Nonspatial Sequence Coding in CA1 Neurons. J Neurosci. 2016; 36(5):1547-63. PMC: 4737769. DOI: 10.1523/JNEUROSCI.2874-15.2016. View

20.

DuBrow S, Davachi L . Temporal memory is shaped by encoding stability and intervening item reactivation. J Neurosci. 2014; 34(42):13998-4005. PMC: 4198540. DOI: 10.1523/JNEUROSCI.2535-14.2014. View