What Is the Antibody Response and Role in Conferring Natural Immunity After SARS-CoV-2 Infection? Rapid, Living Practice Points From the American College of Physicians (Version 1)

Overview

Journal Ann Intern Med

Specialty General Medicine

Date 2021 Mar 15

PMID 33721518

Citations 2

Authors

Amir Qaseem

Jennifer Yost

Itziar Etxeandia-Ikobaltzeta

Mary Ann Forciea

George M Abraham

Matthew C. Miller

Adam J. Obley

Linda L Humphrey

Robert M Centor

Elie A Akl

Rebecca Andrews

Thomas A Bledsoe

Ray Haeme

Devan L Kansagara

Affiliations

Soon will be listed here.

Abstract

Description: The widespread availability of SARS-CoV-2 antibody tests raises important questions for clinicians, patients, and public health professionals related to the appropriate use and interpretation of these tests. The Scientific Medical Policy Committee (SMPC) of the American College of Physicians developed these rapid, living practice points to summarize the current and best available evidence on the antibody response to SARS-CoV-2 infection, antibody durability after initial infection with SARS-CoV-2, and antibody protection against reinfection with SARS-CoV-2.

Methods: The SMPC developed these rapid, living practice points based on a rapid and living systematic evidence review done by the Portland VA Research Foundation and funded by the Agency for Healthcare Research and Quality. Ongoing literature surveillance is planned through December 2021. When new studies are identified and a full update of the evidence review is published, the SMPC will assess the new evidence and any effect on the practice points.

Practice Point 1:

Practice Point 2:

Practice Point 3:

Citing Articles

Real-world utilization of SARS-CoV-2 serological testing in RNA positive patients across the United States.

Rodriguez-Watson C, Sheils N, Louder A, Eldridge E, Lin N, Pollock B PLoS One. 2023; 18(2):e0281365.

PMID: 36763574 PMC: 9916659. DOI: 10.1371/journal.pone.0281365.

What Is the Antibody Response and Role in Conferring Natural Immunity After SARS-CoV-2 Infection? Rapid, Living Practice Points From the American College of Physicians (Version 2).

Qaseem A, Yost J, Etxeandia-Ikobaltzeta I, Forciea M, Abraham G, Miller M Ann Intern Med. 2022; 175(4):556-565.

PMID: 35073153 PMC: 8803138. DOI: 10.7326/M21-3272.

References

Addetia A, Crawford K, Dingens A, Zhu H, Roychoudhury P, Huang M . Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate. J Clin Microbiol. 2020; 58(11). PMC: 7587101. DOI: 10.1128/JCM.02107-20. View

Chirathaworn C, Sripramote M, Chalongviriyalert P, Jirajariyavej S, Kiatpanabhikul P, Saiyarin J . SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020. PLoS One. 2020; 15(10):e0236905. PMC: 7595404. DOI: 10.1371/journal.pone.0236905. View

Akl E, Meerpohl J, Elliott J, Kahale L, Schunemann H . Living systematic reviews: 4. Living guideline recommendations. J Clin Epidemiol. 2017; 91:47-53. DOI: 10.1016/j.jclinepi.2017.08.009. View

Sun B, Feng Y, Mo X, Zheng P, Wang Q, Li P . Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerg Microbes Infect. 2020; 9(1):940-948. PMC: 7273175. DOI: 10.1080/22221751.2020.1762515. View

Liu J, Lian R, Zhang G, Hou B, Wang C, Dong J . Changes in serum virus-specific IgM/IgG antibody in asymptomatic and discharged patients with reoccurring positive COVID-19 nucleic acid test (RPNAT). Ann Med. 2020; 53(1):34-42. PMC: 7544917. DOI: 10.1080/07853890.2020.1811887. View

Zheng Y, Yan M, Wang L, Luan L, Liu J, Tian X . Analysis of the application value of serum antibody detection for staging of COVID-19 infection. J Med Virol. 2020; 93(2):899-906. PMC: 7404947. DOI: 10.1002/jmv.26330. View

Traugott M, Aberle S, Aberle J, Griebler H, Karolyi M, Pawelka E . Performance of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Assays in Different Stages of Infection: Comparison of Commercial Enzyme-Linked Immunosorbent Assays and Rapid Tests. J Infect Dis. 2020; 222(3):362-366. PMC: 7542676. DOI: 10.1093/infdis/jiaa305. View

Liu R, Liu X, Yuan L, Han H, Shereen M, Zhen J . Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Int Immunopharmacol. 2020; 86:106746. PMC: 7318959. DOI: 10.1016/j.intimp.2020.106746. View

Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y . Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019. Clin Infect Dis. 2020; 71(16):2027-2034. PMC: 7184337. DOI: 10.1093/cid/ciaa344. View

10.

Qu J, Wu C, Li X, Zhang G, Jiang Z, Li X . Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020; 71(16):2255-2258. PMC: 7197626. DOI: 10.1093/cid/ciaa489. View

11.

Bruni M, Cecatiello V, Diaz-Basabe A, Lattanzi G, Mileti E, Monzani S . Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers. J Clin Med. 2020; 9(10). PMC: 7600936. DOI: 10.3390/jcm9103188. View

12.

Van Elslande J, Decru B, Jonckheere S, Van Wijngaerden E, Houben E, Vandecandelaere P . Antibody response against SARS-CoV-2 spike protein and nucleoprotein evaluated by four automated immunoassays and three ELISAs. Clin Microbiol Infect. 2020; 26(11):1557.e1-1557.e7. PMC: 7834107. DOI: 10.1016/j.cmi.2020.07.038. View

13.

Theel E, Harring J, Hilgart H, Granger D . Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2. J Clin Microbiol. 2020; 58(8). PMC: 7383546. DOI: 10.1128/JCM.01243-20. View

14.

Shen B, Zheng Y, Zhang X, Zhang W, Wang D, Jin J . Clinical evaluation of a rapid colloidal gold immunochromatography assay for SARS-Cov-2 IgM/IgG. Am J Transl Res. 2020; 12(4):1348-1354. PMC: 7191168. View

15.

Suthar M, Zimmerman M, Kauffman R, Mantus G, Linderman S, Hudson W . Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Rep Med. 2020; 1(3):100040. PMC: 7276302. DOI: 10.1016/j.xcrm.2020.100040. View

16.

Liu J, Guo J, Xu Q, Cai G, Chen D, Shen Y . Detection of IgG antibody during the follow-up in patients with COVID-19 infection. Crit Care. 2020; 24(1):448. PMC: 7370261. DOI: 10.1186/s13054-020-03138-4. View

17.

Hou H, Wang T, Zhang B, Luo Y, Mao L, Wang F . Detection of IgM and IgG antibodies in patients with coronavirus disease 2019. Clin Transl Immunology. 2020; 9(5):e01136. PMC: 7202656. DOI: 10.1002/cti2.1136. View

18.

Flannery D, Gouma S, Dhudasia M, Mukhopadhyay S, Pfeifer M, Woodford E . SARS-CoV-2 seroprevalence among parturient women in Philadelphia. Sci Immunol. 2020; 5(49). PMC: 7594018. DOI: 10.1126/sciimmunol.abd5709. View

19.

Koblischke M, Traugott M, Medits I, Spitzer F, Zoufaly A, Weseslindtner L . Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease Severity. Front Med (Lausanne). 2020; 7:592629. PMC: 7686651. DOI: 10.3389/fmed.2020.592629. View

20.

Iversen K, Bundgaard H, Hasselbalch R, Kristensen J, Nielsen P, Pries-Heje M . Risk of COVID-19 in health-care workers in Denmark: an observational cohort study. Lancet Infect Dis. 2020; 20(12):1401-1408. PMC: 7398038. DOI: 10.1016/S1473-3099(20)30589-2. View