Outcomes of COVID-19 Patients with Comorbidities in Southwest Nigeria

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Mar 15

PMID 33720975

Citations 38

Authors

Akin Osibogun

Mobolanle Balogun

Akin Abayomi

Jide Idris

Yetunde Kuyinu

Oluwakemi Odukoya

Ololade Wright

Remi Adeseun

Bamidele Mutiu

Babatunde Saka

Nike Osa

Dayo Lajide

Ismael Abdus-Salam

Bodunrin Osikomaiya

Oluwatosin Onasanya

Bisola Adebayo

Yewande Oshodi

Sunday Adesola

Olu Adejumo

Olufemi Erinoso

Hussein Abdur-Razzaq

Abimbola Bowale

Kingsley Akinroye

Affiliations

Soon will be listed here.

Abstract

Background: Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African populations. This study identifies comorbidities that predict death among a large sample of COVID-19 patients from Nigeria.

Methods: This was a retrospective analysis of medical records for 2184 laboratory confirmed cases of COVID-19 in Lagos, southwest Nigeria. Extracted data included age, sex, severity of condition at presentation and self-reported comorbidities. The outcomes of interest were death or discharge from facility.

Results: Most of the cases were male (65.8%) and the median age was 43 years (IQR: 33-55). Four hundred and ninety-two patients (22.5%) had at least one comorbidity and the most common amongst them were hypertension (74.2%) and diabetes (30.3%). The mortality rate was 3.3% and a significantly higher proportion of patients with comorbidities died compared to those with none. The comorbidities that predicted death were hypertension (OR: 2.21, 95%CI: 1.22-4.01), diabetes (OR: 3.69, 95% CI: 1.99-6.85), renal disease (OR: 12.53, 95%CI: 1.97-79.56), cancer (OR: 14.12, 95% CI: 2.03-98.19) and HIV (OR: 1.77-84.15].

Conclusion: Comorbidities are prevalent and the associated risk of death is high among COVID-19 patients in Lagos, Nigeria. Public enlightenment, early identification and targeted care for COVID-19 cases with comorbidities are recommended as the pandemic evolves.

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