Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer

Overview

Journal ACS Appl Mater Interfaces

Publisher American Chemical Society

Specialties Biomedical Engineering
Biotechnology

Date 2021 Mar 15

PMID 33719410

Citations 6

Authors

Irene Villa

Chiara Villa

Roberta Crapanzano

Valeria Secchi

Massimo Tawfilas

Elena Trombetta

Laura Porretti

Andrea Brambilla

Marcello Campione

Yvan Torrente

Anna Vedda

Angelo Monguzzi

Affiliations

Soon will be listed here.

Abstract

As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested , showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.

Citing Articles

The role of energy deposition on the luminescence sensitization in porphyrin-functionalized SiO/ZnO nanoparticles under X-ray excitation.

Villa I, Crapanzano R, Mostoni S, Bulin A, DArienzo M, Di Credico B Nanoscale Adv. 2025; 7(5):1464-1474.

PMID: 39866174 PMC: 11758577. DOI: 10.1039/d4na00640b.

Toward "super-scintillation" with nanomaterials and nanophotonics.

Carr Delgado H, Moradifar P, Chinn G, Levin C, Dionne J Nanophotonics. 2024; 13(11):1953-1962.

PMID: 38745841 PMC: 11090085. DOI: 10.1515/nanoph-2023-0946.

Noninvasive Treatment of Alzheimer's Disease with Scintillating Nanotubes.

Senapati S, Secchi V, Cova F, Richman M, Villa I, Yehuda R Adv Healthc Mater. 2023; 12(32):e2301527.

PMID: 37826854 PMC: 11469333. DOI: 10.1002/adhm.202301527.

Energy Partitioning in Multicomponent Nanoscintillators for Enhanced Localized Radiotherapy.

Secchi V, Cova F, Villa I, Babin V, Nikl M, Campione M ACS Appl Mater Interfaces. 2023; 15(20):24693-24700.

PMID: 37172016 PMC: 10214376. DOI: 10.1021/acsami.3c00853.

Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential.

Li J, Wang S, Fontana F, Tapeinos C, Shahbazi M, Han H Bioact Mater. 2022; 23:471-507.

PMID: 36514388 PMC: 9727595. DOI: 10.1016/j.bioactmat.2022.11.013.

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