Microstructural Changes in the Spinal Cord of Adults with Cerebral Palsy

Overview

Journal Dev Med Child Neurol

Date 2021 Mar 15

PMID 33719037

Citations 11

Authors

Michael P Trevarrow

Sarah E Baker

Tony W Wilson

Max J Kurz

Affiliations

Soon will be listed here.

Abstract

Aim: To quantify the microstructural differences in the cervical-thoracic spinal cord of adults with cerebral palsy (CP).

Method: Magnetic resonance imaging of the proximal spinal cord (C6-T3) was conducted on a cohort of adults with CP (n=13; mean age=31y 11mo, standard deviation [SD] 8y 7mo; range=20y 8mo-47y 6mo; eight females, five males) and population norm adult controls (n=16; mean age=31y 4mo, SD 9y 9mo; range=19y 4mo-49y 5mo; seven females, nine males). The cross-sectional area (CSA) of the spinal cord, gray and white matter, magnetization transfer ratio (MTR), and fractional anisotropy of the cuneatus and corticospinal tracts were calculated.

Results: The total spinal cord CSA and proportion of the spinal cord gray matter CSA were significantly decreased in the adults with CP. The corticospinal tracts' MTR was lower in the adults with CP. Individuals that had reduced gray matter also tended to have reduced MTR in their corticospinal tracts (r=0.42, p=0.029) and worse hand dexterity clinical scores (r=0.53, p=0.004).

Interpretation: These results show that there are changes in the spinal cord microstructure of adults with CP. Ultimately, these microstructural changes play a role in the extent of the hand sensorimotor deficits seen in adults with CP. What this paper adds Adults with cerebral palsy (CP) have a reduced spinal cord cross-sectional area (CSA). Spinal cord gray matter is reduced in adults with CP. Spinal cord CSA is associated with hand dexterity. Magnetization transfer ratio of corticospinal tracts was lower in adults with CP.

Citing Articles

Motor practice related changes in the sensorimotor cortices of youth with cerebral palsy.

Kurz M, Taylor B, Heinrichs-Graham E, Spooner R, Baker S, Wilson T Brain Commun. 2024; 6(5):fcae332.

PMID: 39391334 PMC: 11465084. DOI: 10.1093/braincomms/fcae332.

Contributions of the sensory system to motor learning : Focus on Cerebral Palsy.

Kurz M, Busboom M Pediatr Res. 2024; .

PMID: 39068271 DOI: 10.1038/s41390-024-03421-y.

A preliminary study on the spasticity reduction of quadriceps after selective dorsal rhizotomy in pediatric cases of spastic cerebral palsy.

Jiang W, Zhang L, Wei M, Wang R, Xiao B, Wang J Acta Neurochir (Wien). 2024; 166(1):108.

PMID: 38409557 DOI: 10.1007/s00701-024-06010-4.

Disruption of Sensorimotor Cortical Oscillations by Visual Interference Predicts the Altered Motor Performance of Persons with Cerebral Palsy.

Busboom M, Hoffman R, Spooner R, Taylor B, Baker S, Trevarrow M Neuroscience. 2023; 536():92-103.

PMID: 37996052 PMC: 10843825. DOI: 10.1016/j.neuroscience.2023.11.017.

Reduced brainstem volume is associated with mobility impairments in youth with cerebral palsy.

Trevarrow M, Dukkipati S, Baker S, Wilson T, Kurz M J Clin Neurosci. 2023; 117:114-119.

PMID: 37801875 PMC: 10841759. DOI: 10.1016/j.jocn.2023.09.025.

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