Desmoid Fibromatosis: Management in an Era of Increasing Options

Overview

Journal Curr Oncol Rep

Publisher Current Science

Specialty Oncology

Date 2021 Mar 15

PMID 33719012

Citations 15

Authors

Ravin Ratan

Christina L Roland

Andrew J Bishop

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Desmoid fibromatosis (DF) is a locally aggressive clonal neoplasm with locally aggressive behavior and no metastatic potential. Historical treatment of DF has consisted primarily of up-front surgery when feasible. In recent years, recognition that DF can spontaneously stabilize or involute has allowed for many patients to be managed with watchful waiting rather than intervention. This review is intended to review recent developments in the treatment of DF.

Recent Findings: Recent studies have demonstrated prospectively that patients with DF often have improvement in their lesions without intervention, enabling an initial period of surveillance as a standard option for patients with mild symptoms. Given the lengthening list of effective systemic treatments, including sorafenib, pazopanib, and experimental agents, there has been a less reliance on local therapies for those patients who require treatment. For patients with DF that require treatment, there is a growing list of options that includes radiation therapy (RT), percutaneous ablation, and a growing list of systemic agents with favorable toxicity profiles.

Citing Articles

Transarterial doxorubicin-eluting beads embolization for the treatment of desmoid fibromatosis in the pubic region.

Tuan N, Hai T, Minh L, Than T, Tu P, Bao N Radiol Case Rep. 2024; 19(10):4335-4340.

PMID: 39170777 PMC: 11338108. DOI: 10.1016/j.radcr.2024.06.086.

Real-life experience with sorafenib for advanced and refractory desmoid-type fibromatosis.

Schampers D, Decruyenaere A, Jacobs C, Lapeire L Acta Oncol. 2024; 63:607-611.

PMID: 39099320 PMC: 11332451. DOI: 10.2340/1651-226X.2024.40583.

Physiotherapeutic Approach Toward Restoring Upper Limb Function Post the Surgical Excision of Desmoid Fibromatosis Tumor Over the Right Upper Arm.

Ratnani G, Athawale V, Nathani H Cureus. 2024; 16(3):e57098.

PMID: 38681465 PMC: 11053363. DOI: 10.7759/cureus.57098.

Current Treatment Concepts for Extra-Abdominal Desmoid-Type Fibromatosis: A Narrative Review.

Lee Y, Joo M, Shin S, Hong S, Chung Y Cancers (Basel). 2024; 16(2).

PMID: 38254764 PMC: 10813957. DOI: 10.3390/cancers16020273.

Efficacy and safety of different thermal ablative therapies for desmoid-type fibromatosis: a systematic review and meta-analysis.

Huang K, Hong R, Luo L, Zhao H, Wang Y, Li Y Quant Imaging Med Surg. 2023; 13(10):6683-6697.

PMID: 37869315 PMC: 10585570. DOI: 10.21037/qims-23-289.

References

Reitamo J, Hayry P, Nykyri E, SAXEN E . The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population. Am J Clin Pathol. 1982; 77(6):665-73. DOI: 10.1093/ajcp/77.6.665. View

Crago A, Chmielecki J, Rosenberg M, OConnor R, Byrne C, Wilder F . Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis. Genes Chromosomes Cancer. 2015; 54(10):606-15. PMC: 4548882. DOI: 10.1002/gcc.22272. View

Penel N, Chibon F, Salas S . Adult desmoid tumors: biology, management and ongoing trials. Curr Opin Oncol. 2017; 29(4):268-274. PMC: 5470853. DOI: 10.1097/CCO.0000000000000374. View

Nieuwenhuis M, Lefevre J, Bulow S, Jarvinen H, Bertario L, Kerneis S . Family history, surgery, and APC mutation are risk factors for desmoid tumors in familial adenomatous polyposis: an international cohort study. Dis Colon Rectum. 2011; 54(10):1229-34. DOI: 10.1097/DCR.0b013e318227e4e8. View

Lewis J, Boland P, Leung D, Woodruff J, Brennan M . The enigma of desmoid tumors. Ann Surg. 1999; 229(6):866-72; discussion 872-3. PMC: 1420834. DOI: 10.1097/00000658-199906000-00014. View

Bonvalot S, Eldweny H, Haddad V, Rimareix F, Missenard G, Oberlin O . Extra-abdominal primary fibromatosis: Aggressive management could be avoided in a subgroup of patients. Eur J Surg Oncol. 2007; 34(4):462-8. DOI: 10.1016/j.ejso.2007.06.006. View

Fiore M, Rimareix F, Mariani L, Domont J, Collini P, Le Pechoux C . Desmoid-type fibromatosis: a front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol. 2009; 16(9):2587-93. DOI: 10.1245/s10434-009-0586-2. View

Briand S, Barbier O, Biau D, Bertrand-Vasseur A, Larousserie F, Anract P . Wait-and-see policy as a first-line management for extra-abdominal desmoid tumors. J Bone Joint Surg Am. 2014; 96(8):631-8. DOI: 10.2106/JBJS.M.00988. View

Penel N, Cesne A, Bonvalot S, Giraud A, Bompas E, Rios M . Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: A nationwide prospective cohort from the French Sarcoma Group. Eur J Cancer. 2017; 83:125-131. DOI: 10.1016/j.ejca.2017.06.017. View

10.

Kasper B, Baumgarten C, Garcia J, Bonvalot S, Haas R, Haller F . An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group.... Ann Oncol. 2017; 28(10):2399-2408. PMC: 5834048. DOI: 10.1093/annonc/mdx323. View

11.

Wirth L, Klein A, Baur-Melnyk A, Knosel T, Lindner L, Roeder F . Desmoid Tumours of the extremity and trunk. A retrospective study of 44 patients. BMC Musculoskelet Disord. 2018; 19(1):2. PMC: 5756424. DOI: 10.1186/s12891-017-1924-3. View

12.

Smith K, Desai J, Lazarakis S, Gyorki D . Systematic Review of Clinical Outcomes Following Various Treatment Options for Patients with Extraabdominal Desmoid Tumors. Ann Surg Oncol. 2018; 25(6):1544-1554. DOI: 10.1245/s10434-018-6408-7. View

13.

Bishop A, Zarzour M, Ratan R, Torres K, Feig B, Wang W . Long-Term Outcomes for Patients With Desmoid Fibromatosis Treated With Radiation Therapy: A 10-Year Update and Re-evaluation of the Role of Radiation Therapy for Younger Patients. Int J Radiat Oncol Biol Phys. 2018; 103(5):1167-1174. DOI: 10.1016/j.ijrobp.2018.12.012. View

14.

Bates J, Morris C, Iovino N, Rutenberg M, Zlotecki R, Gibbs C . Radiation Therapy for Aggressive Fibromatosis: The Association Between Local Control and Age. Int J Radiat Oncol Biol Phys. 2018; 100(4):997-1003. DOI: 10.1016/j.ijrobp.2017.12.259. View

15.

Bishop A, Landry J, Roland C, Ratan R, Feig B, Moon B . Certain risk factors for patients with desmoid tumors warrant reconsideration of local therapy strategies. Cancer. 2020; 126(14):3265-3273. PMC: 7748083. DOI: 10.1002/cncr.32921. View

16.

Crago A, Denton B, Salas S, Dufresne A, Mezhir J, Hameed M . A prognostic nomogram for prediction of recurrence in desmoid fibromatosis. Ann Surg. 2013; 258(2):347-53. PMC: 4096320. DOI: 10.1097/SLA.0b013e31828c8a30. View

17.

Guadagnolo B, Zagars G, Ballo M . Long-term outcomes for desmoid tumors treated with radiation therapy. Int J Radiat Oncol Biol Phys. 2007; 71(2):441-7. DOI: 10.1016/j.ijrobp.2007.10.013. View

18.

Kujak J, Liu P, Johnson G, Callstrom M . Early experience with percutaneous cryoablation of extra-abdominal desmoid tumors. Skeletal Radiol. 2009; 39(2):175-82. DOI: 10.1007/s00256-009-0801-z. View

19.

Cornelis F, Italiano A, Al-Ammari S, Kind M, Stoeckle E, Gangi A . Successful iterative percutaneous cryoablation of multiple extraabdominal desmoid tumors in a patient with Gardner syndrome. J Vasc Interv Radiol. 2012; 23(8):1101-3. DOI: 10.1016/j.jvir.2012.05.041. View

20.

Havez M, Lippa N, Al-Ammari S, Kind M, Stoeckle E, Italiano A . Percutaneous image-guided cryoablation in inoperable extra-abdominal desmoid tumors: a study of tolerability and efficacy. Cardiovasc Intervent Radiol. 2014; 37(6):1500-6. DOI: 10.1007/s00270-013-0830-9. View