Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Mar 15

PMID 33718361

Citations 7

Authors

Yanan Hua

Jinlian Song

Cuixiu Peng

Runze Wang

Zhongliang Ma

Jinyu Zhang

Zheng Zhang

Ning Li

Lin Hou

Affiliations

Soon will be listed here.

Abstract

A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington's disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.

Citing Articles

Regulator of Ribosome Synthesis 1 (RRS1) Stabilizes GRP78 and Promotes Breast Cancer Progression.

Sun W, Song J, Wu Q, Deng L, Zhang T, Zhang L Molecules. 2024; 29(5).

PMID: 38474562 PMC: 10934892. DOI: 10.3390/molecules29051051.

Long noncoding RNA SNHG1 promotes breast cancer progression by regulating the miR-641/RRS1 axis.

Deng L, Wang J, Song J, Wu Q, Gong Z, Song J Sci Rep. 2024; 14(1):3265.

PMID: 38331968 PMC: 10853250. DOI: 10.1038/s41598-024-52953-0.

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.

Yamashita A, Ignatenko O, Nguyen M, Lambert R, Watt K, Daneault C Biol Direct. 2023; 18(1):60.

PMID: 37736739 PMC: 10515011. DOI: 10.1186/s13062-023-00416-3.

Genomic gain/methylation modification/hsa-miR-132-3p increases RRS1 overexpression in liver hepatocellular carcinoma.

Zhang X, Cong P, Tian L, Zheng Y, Zhang H, Liu Q Cancer Sci. 2023; 114(11):4329-4342.

PMID: 37705317 PMC: 10637089. DOI: 10.1111/cas.15933.

Integrated bioinformatics and machine-learning screening for immune-related genes in diagnosing non-alcoholic fatty liver disease with ischemic stroke and RRS1 pan-cancer analysis.

Bao H, Li J, Zhang B, Huang J, Su D, Liu L Front Immunol. 2023; 14:1113634.

PMID: 37090698 PMC: 10115222. DOI: 10.3389/fimmu.2023.1113634.

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