Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Mar 15

PMID 33718216

Citations 6

Authors

Lama Elbahlawan

John Bissler

R Ray Morrison

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cell transplant (HSCT) is a curative therapy for malignant and non-malignant conditions. However, complications post-HSCT contribute to significant morbidity and mortality in this population. Acute kidney injury (AKI) is common in the post-allogeneic transplant phase and contributes to morbidity in this population. Continuous renal replacement therapy (CRRT) is used often in the setting of AKI or multiorgan dysfunction in critically ill children. In addition, CRRT can be useful in many disease processes related to transplant and can potentially improve outcomes in this population. This review will focus on the use of CRRT in critically ill children in the post-HSCT setting outside the realm of acute renal failure and highlight the benefits and applications of this modality in this high-risk population.

Citing Articles

Editorial: Critical complications in pediatric oncology and hematopoietic cell transplant, volume II.

McArthur J, Mahadeo K, Agulnik A, Steiner M Front Oncol. 2024; 14:1512659.

PMID: 39555452 PMC: 11564162. DOI: 10.3389/fonc.2024.1512659.

Fluid Overload in Children Following Hematopoietic Cell Transplant: A Comprehensive Review.

Elbahlawan L, Qudeimat A, Morrison R, Schaller A J Clin Med. 2024; 13(21).

PMID: 39518488 PMC: 11546381. DOI: 10.3390/jcm13216348.

Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients.

Liu Y, Liu Y, Chen X, Jia Y Front Cell Infect Microbiol. 2023; 13:1223824.

PMID: 37790911 PMC: 10543755. DOI: 10.3389/fcimb.2023.1223824.

Kidney Injury in Children after Hematopoietic Stem Cell Transplant.

James V, Angelo J, Elbahlawan L Curr Oncol. 2023; 30(3):3329-3343.

PMID: 36975466 PMC: 10047595. DOI: 10.3390/curroncol30030253.

Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus.

Raina R, Abu-Arja R, Sethi S, Dua R, Chakraborty R, Dibb J Pediatr Nephrol. 2022; 37(6):1179-1203.

PMID: 35224659 DOI: 10.1007/s00467-022-05448-x.

References

Rondon G, Saliba R, Chen J, Ledesma C, Alousi A, Oran B . Impact of Fluid Overload as New Toxicity Category on Hematopoietic Stem Cell Transplantation Outcomes. Biol Blood Marrow Transplant. 2017; 23(12):2166-2171. PMC: 5889108. DOI: 10.1016/j.bbmt.2017.08.021. View

Raymakers-Janssen P, Lilien M, Tibboel D, Kneyber M, Dijkstra S, van Woensel J . Epidemiology and Outcome of Critically Ill Pediatric Cancer and Hematopoietic Stem Cell Transplant Patients Requiring Continuous Renal Replacement Therapy: A Retrospective Nationwide Cohort Study. Crit Care Med. 2019; 47(11):e893-e901. PMC: 6798750. DOI: 10.1097/CCM.0000000000003973. View

Khwaja A . KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012; 120(4):c179-84. DOI: 10.1159/000339789. View

Fayad A, Buamscha D, Ciapponi A . Intensity of continuous renal replacement therapy for acute kidney injury. Cochrane Database Syst Rev. 2016; 10:CD010613. PMC: 6457961. DOI: 10.1002/14651858.CD010613.pub2. View

Warrillow S, Fisher C, Tibballs H, Bailey M, McArthur C, Lawson-Smith P . Continuous renal replacement therapy and its impact on hyperammonaemia in acute liver failure. Crit Care Resusc. 2020; 22(2):158-165. PMC: 10692487. View

Gutgarts V, Jain T, Zheng J, Maloy M, Ruiz J, Pennisi M . Acute Kidney Injury after CAR-T Cell Therapy: Low Incidence and Rapid Recovery. Biol Blood Marrow Transplant. 2020; 26(6):1071-1076. PMC: 8375362. DOI: 10.1016/j.bbmt.2020.02.012. View

Li Y, Li H, Zhang D . Timing of continuous renal replacement therapy in patients with septic AKI: A systematic review and meta-analysis. Medicine (Baltimore). 2019; 98(33):e16800. PMC: 6831327. DOI: 10.1097/MD.0000000000016800. View

Koh K, Sunkara A, Guolian Kang , Sooter A, Mulrooney D, Triplett B . Acute Kidney Injury in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation: Incidence, Risk Factors, and Outcomes. Biol Blood Marrow Transplant. 2017; 24(4):758-764. DOI: 10.1016/j.bbmt.2017.11.021. View

Cardoso F, Gottfried M, Tujios S, Olson J, Karvellas C . Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure. Hepatology. 2017; 67(2):711-720. PMC: 5832542. DOI: 10.1002/hep.29488. View

10.

Tsujimoto H, Tsujimoto Y, Nakata Y, Fujii T, Takahashi S, Akazawa M . Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2020; 12:CD012467. PMC: 8812343. DOI: 10.1002/14651858.CD012467.pub3. View

11.

DSouza A, Fretham C, Lee S, Arora M, Brunner J, Chhabra S . Current Use of and Trends in Hematopoietic Cell Transplantation in the United States. Biol Blood Marrow Transplant. 2020; 26(8):e177-e182. PMC: 7404814. DOI: 10.1016/j.bbmt.2020.04.013. View

12.

Fitzgerald J, Weiss S, Maude S, Barrett D, Lacey S, Melenhorst J . Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia. Crit Care Med. 2016; 45(2):e124-e131. PMC: 5452983. DOI: 10.1097/CCM.0000000000002053. View

13.

Park J, Lee H, Kee Y, Park S, Oh H, Han S . High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial. Am J Kidney Dis. 2016; 68(4):599-608. DOI: 10.1053/j.ajkd.2016.02.049. View

14.

Zhang W, Bai M, Yu Y, Li L, Zhao L, Sun S . Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: a systematic review and meta-analysis. Crit Care. 2019; 23(1):22. PMC: 6345001. DOI: 10.1186/s13054-019-2317-9. View

15.

Elbahlawan L, West N, Avent Y, Cheng C, Liu W, Barfield R . Impact of continuous renal replacement therapy on oxygenation in children with acute lung injury after allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010; 55(3):540-5. PMC: 3214656. DOI: 10.1002/pbc.22561. View

16.

Flores F, Brophy P, Symons J, Fortenberry J, Chua A, Alexander S . Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group. Pediatr Nephrol. 2008; 23(4):625-30. DOI: 10.1007/s00467-007-0672-2. View

17.

DiCarlo J, Alexander S . Acute kidney injury in pediatric stem cell transplant recipients. Semin Nephrol. 2008; 28(5):481-7. DOI: 10.1016/j.semnephrol.2008.05.008. View

18.

Panphanpho S, Naowapanich S, Ratanarat R . Use of saline flush to prevent filter clotting in continuous renal replacement therapy without anticoagulant. J Med Assoc Thai. 2011; 94 Suppl 1:S105-10. View

19.

Rajasekaran S, Jones D, Avent Y, Shaffer M, Elbahlawan L, Henderson N . Outcomes of hematopoietic stem cell transplant patients who received continuous renal replacement therapy in a pediatric oncology intensive care unit. Pediatr Crit Care Med. 2010; 11(6):699-706. DOI: 10.1097/PCC.0b013e3181e32423. View

20.

Barker C, Butzner J, Anderson R, Brant R, Sauve R . Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2003; 32(1):79-87. DOI: 10.1038/sj.bmt.1704069. View