The Double-edged Sword of Tregs in M Tuberculosis, M Avium, and M Absessus Infection

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2021 Mar 13

PMID 33713043

Citations 4

Authors

Deepshikha Verma

Edward D Chan

Diane J Ordway

Affiliations

Soon will be listed here.

Abstract

Immunity against different Mycobacteria species targeting the lung requires distinctly different pulmonary immune responses for bacterial clearance. Many parameters of acquired and regulatory immune responses differ quantitatively and qualitatively from immunity during infection with Mycobacteria species. Nontuberculosis Mycobacteria species (NTM) Mycobacterium avium- (M avium), Mycobacterium abscessus-(M abscessus), and the Mycobacteria species Mycobacterium tuberculosis-(Mtb). Herein, we discuss the potential implications of acquired and regulatory immune responses in the context of animal and human studies, as well as future directions for efforts to treat Mycobacteria diseases.

Citing Articles

Specificity of the innate immune responses to different classes of non-tuberculous mycobacteria.

Hu W, Koch B, Lamers G, Forn-Cuni G, Spaink H Front Immunol. 2023; 13:1075473.

PMID: 36741407 PMC: 9890051. DOI: 10.3389/fimmu.2022.1075473.

Clinical Significance of Negative Costimulatory Molecule PD-1/PD-L1 on Peripheral Blood Regulatory T Cell Levels among Patients with Pulmonary Tuberculosis.

Yang C, Dai F, Pulati R, Jiao Y, Xu Q J Trop Med. 2022; 2022:7526501.

PMID: 36035072 PMC: 9410994. DOI: 10.1155/2022/7526501.

Protective Efficacy of BCG Vaccine against and Non-Tuberculous Mycobacterial Infections.

Orujyan D, Narinyan W, Rangarajan S, Rangchaikul P, Prasad C, Saviola B Vaccines (Basel). 2022; 10(3).

PMID: 35335022 PMC: 8952781. DOI: 10.3390/vaccines10030390.

Study on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms.

Su Q, Liu Q, Liu J, Fu L, Liu T, Liang J Bioengineered. 2021; 12(2):11700-11708.

PMID: 34872459 PMC: 8810084. DOI: 10.1080/21655979.2021.2003930.

References

Savage N, de Boer T, Walburg K, Joosten S, van Meijgaarden K, Geluk A . Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J Immunol. 2008; 181(3):2220-6. DOI: 10.4049/jimmunol.181.3.2220. View

Caudy A, Reddy S, Chatila T, Atkinson J, Verbsky J . CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol. 2007; 119(2):482-7. DOI: 10.1016/j.jaci.2006.10.007. View

Chan E, Verma D, Ordway D . Animal Models of Mycobacteria Infection. Curr Protoc Immunol. 2020; 129(1):e98. DOI: 10.1002/cpim.98. View

Avendano-Ortiz J, Llanos-Gonzalez E, Toledano V, Del Campo R, Cubillos-Zapata C, Lozano-Rodriguez R . Pseudomonas aeruginosa colonization causes PD-L1 overexpression on monocytes, impairing the adaptive immune response in patients with cystic fibrosis. J Cyst Fibros. 2018; 18(5):630-635. DOI: 10.1016/j.jcf.2018.11.002. View

Hector A, Schafer H, Poschel S, Fischer A, Fritzsching B, Ralhan A . Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection. Am J Respir Crit Care Med. 2015; 191(8):914-23. DOI: 10.1164/rccm.201407-1381OC. View

Benard A, Sakwa I, Schierloh P, Colom A, Mercier I, Tailleux L . B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis. Am J Respir Crit Care Med. 2017; 197(6):801-813. PMC: 5855072. DOI: 10.1164/rccm.201707-1475OC. View

Verver S, Warren R, Beyers N, Richardson M, van der Spuy G, Borgdorff M . Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. Am J Respir Crit Care Med. 2005; 171(12):1430-5. DOI: 10.1164/rccm.200409-1200OC. View

Josefowicz S, Lu L, Rudensky A . Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30:531-64. PMC: 6066374. DOI: 10.1146/annurev.immunol.25.022106.141623. View

Kessel A, Haj T, Peri R, Snir A, Melamed D, Sabo E . Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells. Autoimmun Rev. 2011; 11(9):670-7. DOI: 10.1016/j.autrev.2011.11.018. View

10.

Wood K, Bushell A, Hester J . Regulatory immune cells in transplantation. Nat Rev Immunol. 2012; 12(6):417-30. DOI: 10.1038/nri3227. View

11.

Shang S, Gibbs S, Henao-Tamayo M, Shanley C, McDonnell G, Duarte R . Increased virulence of an epidemic strain of Mycobacterium massiliense in mice. PLoS One. 2011; 6(9):e24726. PMC: 3171484. DOI: 10.1371/journal.pone.0024726. View

12.

Iakhiaeva E, Howard S, Brown Elliott B, McNulty S, Newman K, Falkinham 3rd J . Variable-Number Tandem-Repeat Analysis of Respiratory and Household Water Biofilm Isolates of "Mycobacterium avium subsp. hominissuis" with Establishment of a PCR Database. J Clin Microbiol. 2016; 54(4):891-901. PMC: 4809946. DOI: 10.1128/JCM.02409-15. View

13.

Houben R, Dodd P . The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling. PLoS Med. 2016; 13(10):e1002152. PMC: 5079585. DOI: 10.1371/journal.pmed.1002152. View

14.

Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K . Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol. 2010; 184(9):4801-9. PMC: 3734559. DOI: 10.4049/jimmunol.0902385. View

15.

Kaveh D, Bachy V, Hewinson R, Hogarth P . Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge. PLoS One. 2011; 6(6):e21566. PMC: 3123368. DOI: 10.1371/journal.pone.0021566. View

16.

Khattri R, Cox T, Yasayko S, Ramsdell F . An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol. 2003; 4(4):337-42. DOI: 10.1038/ni909. View

17.

Falkinham 3rd J, Norton C, Lechevallier M . Factors influencing numbers of Mycobacterium avium, Mycobacterium intracellulare, and other Mycobacteria in drinking water distribution systems. Appl Environ Microbiol. 2001; 67(3):1225-31. PMC: 92717. DOI: 10.1128/AEM.67.3.1225-1231.2001. View

18.

Zhu B, Dockrell H, Ottenhoff T, Evans T, Zhang Y . Tuberculosis vaccines: Opportunities and challenges. Respirology. 2018; 23(4):359-368. DOI: 10.1111/resp.13245. View

19.

Hori S, Nomura T, Sakaguchi S . Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003; 299(5609):1057-61. DOI: 10.1126/science.1079490. View

20.

Orme I, Ordway D . Mouse and Guinea Pig Models of Tuberculosis. Microbiol Spectr. 2016; 4(4). DOI: 10.1128/microbiolspec.TBTB2-0002-2015. View