Will Mesenchymal Stem Cells Be Future Directions for Treating Radiation-induced Skin Injury?

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2021 Mar 13

PMID 33712078

Citations 6

Authors

Zhuoqun Fang

Penghong Chen

Shijie Tang

Aizhen Chen

Chaoyu Zhang

Guohao Peng

Ming Li

Xiaosong Chen

Affiliations

Soon will be listed here.

Abstract

Radiation-induced skin injury (RISI) is one of the common serious side effects of radiotherapy (RT) for patients with malignant tumors. Mesenchymal stem cells (MSCs) are applied to RISI repair in some clinical cases series except some traditional options. Though direct replacement of damaged cells may be achieved through differentiation capacity of MSCs, more recent data indicate that various cytokines and chemokines secreted by MSCs are involved in synergetic therapy of RISI by anti-inflammatory, immunomodulation, antioxidant, revascularization, and anti-apoptotic activity. In this paper, we not only discussed different sources of MSCs on the treatment of RISI both in preclinical studies and clinical trials, but also summarized the applications and mechanisms of MSCs in other related regenerative fields.

Citing Articles

Impact of Minimally Manipulated Cell Therapy on Immune Responses in Radiation-Induced Skin Wound Healing.

Shestakova V, Smirnova E, Atiakshin D, Kisel A, Koryakin S, Litun E Int J Mol Sci. 2025; 26(5).

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Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems.

Miura Y, Fujii S, Ichinohe T J Radiat Res. 2024; 65(Supplement_1):i80-i87.

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A critical review of the progress in prevention and treatment of radiation-induced skin damage.

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Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression.

Zhang Y, Wang C, Li J Exp Hematol Oncol. 2024; 13(1):64.

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Evaluation of the Composite Skin Patch Loaded with Bioactive Functional Factors Derived from Multicellular Spheres of EMSCs for Regeneration of Full-thickness Skin Defects in Rats.

Zhang X, Shi W, Wang X, Zou Y, Xiang W, Lu N Curr Stem Cell Res Ther. 2023; 19(8):1142-1152.

PMID: 37694794 DOI: 10.2174/1574888X19666230908142426.

References

Ahmed N, Radwan N, Aboul Ezz H, Salama N . The antioxidant effect of Green Tea Mega EGCG against electromagnetic radiation-induced oxidative stress in the hippocampus and striatum of rats. Electromagn Biol Med. 2016; 36(1):63-73. DOI: 10.1080/15368378.2016.1194292. View

Gentile P, Kothari A, Casella D, Calabrese C . Fat Graft Enhanced With Adipose-Derived Stem Cells in Aesthetic Breast Augmentation: Clinical, Histological, and Instrumental Evaluation. Aesthet Surg J. 2019; 40(9):962-977. DOI: 10.1093/asj/sjz292. View

Liu F, Luo X, Shen H, Dong J, Yang J . Using human hair follicle-derived keratinocytes and melanocytes for constructing pigmented tissue-engineered skin. Skin Res Technol. 2011; 17(3):373-9. DOI: 10.1111/j.1600-0846.2011.00510.x. View

Patel D, Mittal S, Tiwari N, Maurya A, Singh D, Pandey A . Plasmodium-Salmonella Coinfection Induces Intense Inflammatory Response, Oxidative Stress, and Liver Damage: A Mice Model Study for Therapeutic Strategy. Shock. 2018; 50(6):741-749. DOI: 10.1097/SHK.0000000000001111. View

Maillacheruvu P, Engel L, Crum I, Agrawal D, Peeples E . From cord to caudate: characterizing umbilical cord blood stem cells and their paracrine interactions with the injured brain. Pediatr Res. 2017; 83(1-2):205-213. DOI: 10.1038/pr.2017.251. View

Xie M, Gorodetsky R, Micewicz E, Micevicz E, Mackenzie N, Gaberman E . Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. J Invest Dermatol. 2012; 133(2):553-61. PMC: 3519961. DOI: 10.1038/jid.2012.326. View

Guo M, Dong Z, Qiao J, Yu C, Sun Q, Hu K . Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells. J Radiat Res. 2013; 55(2):205-9. PMC: 3951066. DOI: 10.1093/jrr/rrt102. View

Hart P, Norval M, Byrne S, Rhodes L . Exposure to Ultraviolet Radiation in the Modulation of Human Diseases. Annu Rev Pathol. 2018; 14:55-81. DOI: 10.1146/annurev-pathmechdis-012418-012809. View

Xia Z, Zhang C, Zeng Y, Wang T, Ai G . Transplantation of BMSCs expressing hVEGF165 /hBD3 promotes wound healing in rats with combined radiation-wound injury. Int Wound J. 2012; 11(3):293-303. PMC: 7950710. DOI: 10.1111/j.1742-481X.2012.01090.x. View

10.

Oliveira G, Shimoda K, Enkhbaatar P, Jodoin J, Burke A, Chinkes D . Skin nitric oxide and its metabolites are increased in nonburned skin after thermal injuries. Shock. 2004; 22(3):278-82. DOI: 10.1097/01.shk.0000135259.90311.33. View

11.

Bey E, Prat M, Duhamel P, Benderitter M, Brachet M, Trompier F . Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations. Wound Repair Regen. 2010; 18(1):50-8. DOI: 10.1111/j.1524-475X.2009.00562.x. View

12.

Hasoun L, Bailey S, Outlaw K, Ayling J . Rearrangement and depletion of folate in human skin by ultraviolet radiation. Br J Dermatol. 2015; 173(4):1087-90. DOI: 10.1111/bjd.13885. View

13.

Boucai L, Falcone J, Ukena J, Coombs C, Zehir A, Ptashkin R . Radioactive Iodine-Related Clonal Hematopoiesis in Thyroid Cancer Is Common and Associated With Decreased Survival. J Clin Endocrinol Metab. 2018; 103(11):4216-4223. PMC: 6194804. DOI: 10.1210/jc.2018-00803. View

14.

Rodriguez-Menocal L, Shareef S, Salgado M, Shabbir A, Van Badiavas E . Role of whole bone marrow, whole bone marrow cultured cells, and mesenchymal stem cells in chronic wound healing. Stem Cell Res Ther. 2015; 6:24. PMC: 4414366. DOI: 10.1186/s13287-015-0001-9. View

15.

Gomes T, Song Y, Brede D, Xie L, Gutzkow K, Salbu B . Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Sci Total Environ. 2018; 628-629:206-216. DOI: 10.1016/j.scitotenv.2018.02.039. View

16.

Liao Y, Feng G, Dai T, Long F, Tang J, Pu Y . Randomized, self-controlled, prospective assessment of the efficacy of mometasone furoate local application in reducing acute radiation dermatitis in patients with head and neck squamous cell carcinomas. Medicine (Baltimore). 2019; 98(52):e18230. PMC: 6946454. DOI: 10.1097/MD.0000000000018230. View

17.

Riccobono D, Agay D, Scherthan H, Forcheron F, Vivier M, Ballester B . Application of adipocyte-derived stem cells in treatment of cutaneous radiation syndrome. Health Phys. 2012; 103(2):120-6. DOI: 10.1097/HP.0b013e318240595b. View

18.

Altman A, Abdul Khalek F, Alt E, Butler C . Adipose tissue-derived stem cells enhance bioprosthetic mesh repair of ventral hernias. Plast Reconstr Surg. 2010; 126(3):845-854. DOI: 10.1097/PRS.0b013e3181e6044f. View

19.

Hernandez A, Vallejo B, Ruzgas T, Bjorklund S . The Effect of UVB Irradiation and Oxidative Stress on the Skin Barrier-A New Method to Evaluate Sun Protection Factor Based on Electrical Impedance Spectroscopy. Sensors (Basel). 2019; 19(10). PMC: 6566889. DOI: 10.3390/s19102376. View

20.

Fang S, Xu C, Zhang Y, Xue C, Yang C, Bi H . Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing. Stem Cells Transl Med. 2016; 5(10):1425-1439. PMC: 5031180. DOI: 10.5966/sctm.2015-0367. View