Inflammatory Markers and Incident Heart Failure in Older Men: the Role of NT-proBNP

Overview

Journal Biomark Med

Specialties Biochemistry
General Medicine

Date 2021 Mar 12

PMID 33709785

Citations 6

Authors

Douglas Gj McKechnie

A Olia Papacosta

Lucy T Lennon

Paul Welsh

Peter H Whincup

S Goya Wannamethee

Affiliations

Soon will be listed here.

Abstract

To determine the relationship between baseline inflammation (CRP and IL-6) with natriuretic peptide (NP) activity (measured by NT-proBNP) and incident heart failure (HF) in older men. In the British Regional Heart Study, 3569 men without prevalent myocardial infarction or HF were followed for mean 16.3 years; 327 developed HF. Baseline CRP and IL-6 were significantly and positively associated with NT-proBNP. Those in the highest CRP and IL-6 quartiles had an elevated risk of HF after age and BMI adjustment (HR = 1.42 [1.01-1.98] and 1.71 [1.24-2.37], respectively), which markedly attenuated after NT-proBNP adjustment (HR = 1.15 [0.81-1.63] and 1.25 [0.89-1.75], respectively). NP activity is associated with pro-inflammatory biomarkers and may explain the link between inflammation and incident HF.

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