Non-sebaceous Lymphadenoma of the Parotid Gland Mimicking a Pleomorphic Adenoma

Overview

Journal Clin Pathol

Publisher Sage Publications

Date 2021 Mar 12

PMID 33709077

Authors

Carlos Antonio Morales Morales

Alan Ellison Ramos Mayo

Mauricio Gonzalez-Urquijo

Alvaro Barbosa Quintana

Eduardo Alberto Guzman Huerta

Affiliations

Soon will be listed here.

Abstract

Non-sebaceous lymphadenoma of the salivary glands is a rare benign lesion, first described in 1991. We present the case of a 54-year-old woman, with a right parotid mass. She underwent right superficial parotidectomy, and histopathology reported a non-sebaceous lymphadenoma due to an encapsulated lesion and multiple non-atypical epithelial inclusions without sebaceous differentiation. The etiology of non-sebaceous lymphadenoma is not yet understood, but it can arise predominantly from the parotid gland. Surgical excision is the treatment of choice.

References

Weiler C, Agaimy A, Zengel P, Zenk J, Kirchner T, Ihrler S . Nonsebaceous lymphadenoma of salivary glands: proposed development from intraparotid lymph nodes and risk of misdiagnosis. Virchows Arch. 2012; 460(5):467-72. DOI: 10.1007/s00428-012-1225-z. View

Salgarelli A, Cappare P, Bellini P, Collini M . Usefulness of fine-needle aspiration in parotid diagnostics. Oral Maxillofac Surg. 2009; 13(4):185-90. DOI: 10.1007/s10006-009-0182-4. View

Seethala R, Thompson L, Gnepp D, Barnes E, Skalova A, Montone K . Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol. 2011; 25(1):26-35. DOI: 10.1038/modpathol.2011.135. View

Gallego L, Junquera L, Fresno M . Non-sebaceous lymphadenoma of the parotid gland: immunohistochemical study and DNA ploidy analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 107(4):555-8. DOI: 10.1016/j.tripleo.2008.11.018. View

Gnepp D . My journey into the world of salivary gland sebaceous neoplasms. Head Neck Pathol. 2012; 6(1):101-10. PMC: 3311956. DOI: 10.1007/s12105-012-0343-x. View

Gudmundsson J, Ajan A, Abtahi J . The accuracy of fine-needle aspiration cytology for diagnosis of parotid gland masses: a clinicopathological study of 114 patients. J Appl Oral Sci. 2017; 24(6):561-567. PMC: 5161254. DOI: 10.1590/1678-775720160214. View

Kara H, Sonmez S, Bagbudar S, Gulluoglu M, Basaran B . Malignant Transformation of Parotid Gland Non-sebaceous Lymphadenoma: Case Report and Review of Literature. Head Neck Pathol. 2020; 14(4):1123-1128. PMC: 7669958. DOI: 10.1007/s12105-020-01133-3. View

Ma J, Chan J, Chow C, ORELL S . Lymphadenoma: a report of three cases of an uncommon salivary gland neoplasm. Histopathology. 2002; 41(4):342-50. DOI: 10.1046/j.1365-2559.2002.01528.x. View

To V, Chan J, Tsang R, Wei W . Review of salivary gland neoplasms. ISRN Otolaryngol. 2013; 2012:872982. PMC: 3658557. DOI: 10.5402/2012/872982. View

10.

Dardick I, Thomas M . Lymphadenoma of parotid gland: Two additional cases and a literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105(4):491-4. DOI: 10.1016/j.tripleo.2007.08.035. View

11.

Liu C, Jethwa A, Khariwala S, Johnson J, Shin J . Sensitivity, Specificity, and Posttest Probability of Parotid Fine-Needle Aspiration: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2015; 154(1):9-23. PMC: 4896151. DOI: 10.1177/0194599815607841. View

12.

Yang S, Chen X, Wang L, Zhang J . Non-sebaceous lymphadenoma of the salivary gland: case report with immunohistochemical investigation. Virchows Arch. 2007; 450(5):595-9. DOI: 10.1007/s00428-007-0393-8. View

13.

Castelino-Prabhu S, Li Q, Ali S . Nonsebaceous lymphadenoma of the parotid gland: cytopathologic findings and differential diagnosis. Diagn Cytopathol. 2009; 38(2):137-40. DOI: 10.1002/dc.21158. View

14.

Ishii A, Kawano H, Tanaka S, Yamamoto Y, Nakamoto T, Hirose Y . Non-sebaceous lymphadenoma of the salivary gland with serous acinic cell differentiation, a first case report in the literature. Pathol Int. 2013; 63(5):272-6. DOI: 10.1111/pin.12061. View

15.

Haynes J, Arnold K, Aguirre-Oskins C, Chandra S . Evaluation of neck masses in adults. Am Fam Physician. 2015; 91(10):698-706. View

16.

Seethala R, Stenman G . Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017; 11(1):55-67. PMC: 5340736. DOI: 10.1007/s12105-017-0795-0. View