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A Rare Tumor of Clivus Masquerading As Pituitary Adenoma

Overview
Specialty Neurology
Date 2021 Mar 12
PMID 33708696
Citations 1
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Abstract

Giant cell tumors (GCT) are generally benign, commonly affecting young adults, with a slight preponderance in females. They are locally aggressive with a high rate of local recurrence. Most of them are found in the epiphysis of long bones, making the base of the skull a rare site. We report the case of a 35-year-old female, who presented with neurological symptoms of headache and diplopia. On magnetic resonance imaging, a space-occupying lesion was discovered in the clivus. Histopathology was diagnostic of a GCT. GCT arising from the clivus is extremely uncommon, with about 15 cases published in the literature. The present case highlights the rarity of this tumor and contributes to the existing literature with analysis and evaluation of the management strategies and prognosis.

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References
1.
Scotto di Carlo F, Divisato G, Iacoangeli M, Esposito T, Gianfrancesco F . The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location. BMC Cancer. 2018; 18(1):358. PMC: 5880014. DOI: 10.1186/s12885-018-4291-z. View

2.
Satapathy A, Tripathi M, Chauhan R, Gurnaani J, Mohindra S . Giant cell tumor at the clivus: Not an area 51. Neurol India. 2018; 66(3):861-864. DOI: 10.4103/0028-3886.232286. View

3.
Akyigit A, Karlidag T, Sakallioglu O, Polat C, Keles E . Giant cell tumor of bone involving the temporomandibular joint and temporal bone. J Craniofac Surg. 2014; 25(4):1397-9. DOI: 10.1097/SCS.0000000000000876. View

4.
Sharma R, Mahapatra A, Pawar S, Sousa J, Dev E . Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 2001; 9(1):41-50. DOI: 10.1054/jocn.2001.0963. View

5.
Freeman J, Oushy S, Schowinsky J, Sillau S, Youssef A . Invasive Giant Cell Tumor of the Lateral Skull Base: A Systematic Review, Meta-Analysis, and Case Illustration. World Neurosurg. 2016; 96:47-57. DOI: 10.1016/j.wneu.2016.05.086. View