Cardiovascular Protection Effect of Chlorogenic Acid: Focus on the Molecular Mechanism

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2021 Mar 12

PMID 33708382

Citations 7

Authors

Mifetika Lukitasari

Mohammad Saifur Rohman

Dwi Adi Nugroho

Nashi Widodo

Nur Ida Panca Nugrahini

Affiliations

Soon will be listed here.

Abstract

Vascular endothelial cells have a variety of functions such as the control of blood coagulation, vascular permeability, and tone regulation, as well as quiesce of immune cells. Endothelial dysfunction is a cardiovascular events predictor, which is considered the initial stage in atherosclerosis development. It is characterized by alterations in endothelium functions due to imbalanced vasodilators and vasoconstrictors, procoagulant and anticoagulant mediators, as well as growth inhibitor and promotor substances. Chlorogenic acid (CGA) is the primary polyphenol in coffee and some fruits. It has many health-promoting properties, especially in the cardiovascular system. Many studies investigated the efficacy and mechanism of this compound in vascular health. CGA has several vascular benefits such as anti-atherosclerosis, anti-thrombosis, and anti-hypertensive. This review focuses on the molecular mechanism of CGA in vascular health.

Citing Articles

Comparative Analysis of Phenolic Profiles and Antioxidant Activity in the Leaves of Invasive (Lam.) K. Koch in Lithuania.

Saunoriute S, Zymone K, Marksa M, Raudone L Plants (Basel). 2025; 14(2).

PMID: 39861574 PMC: 11769043. DOI: 10.3390/plants14020221.

Determination of Biologically Active Compounds and Antioxidant Capacity In Vitro in Fruit of Small Cranberries ( L.) Growing in Natural Habitats in Lithuania.

Liaudanskas M, Sedbare R, Janulis V Antioxidants (Basel). 2024; 13(9).

PMID: 39334704 PMC: 11428458. DOI: 10.3390/antiox13091045.

Immunoexpression of aortic endothelial P-selectin and serum apolipoprotein A-1 levels after administration of arabica () and robusta () coffee bean extracts: In vivo study in atherosclerosis rat model.

Ekawati W, Heriansyah T, Kamarlis R, Purnawarman A, Sofyan H, Enitan S Narra J. 2024; 4(2):e794.

PMID: 39280317 PMC: 11391985. DOI: 10.52225/narra.v4i2.794.

Bioactive compounds in coffee and their role in lowering the risk of major public health consequences: A review.

Makiso M, Tola Y, Ogah O, Endale F Food Sci Nutr. 2024; 12(2):734-764.

PMID: 38370073 PMC: 10867520. DOI: 10.1002/fsn3.3848.

Recent Updates on the Therapeutics Benefits, Clinical Trials, and Novel Delivery Systems of Chlorogenic Acid for the Management of Diseases with a Special Emphasis on Ulcerative Colitis.

Harwansh R, Bhati H, Deshmukh R Curr Pharm Des. 2024; 30(6):420-439.

PMID: 38299405 DOI: 10.2174/0113816128295753240129074035.

References

Loader T, Taylor C, Zahradka P, Jones P . Chlorogenic acid from coffee beans: evaluating the evidence for a blood pressure-regulating health claim. Nutr Rev. 2017; 75(2):114-133. DOI: 10.1093/nutrit/nuw057. View

Ngo Lemba Tom E, Girard-Thernier C, Demougeot C . The Janus face of chlorogenic acid on vascular reactivity: A study on rat isolated vessels. Phytomedicine. 2016; 23(10):1037-42. DOI: 10.1016/j.phymed.2016.06.012. View

Wu C, Luan H, Zhang X, Wang S, Zhang X, Sun X . Chlorogenic acid protects against atherosclerosis in ApoE-/- mice and promotes cholesterol efflux from RAW264.7 macrophages. PLoS One. 2014; 9(9):e95452. PMC: 4154672. DOI: 10.1371/journal.pone.0095452. View

Boon E, Croft K, Shinde S, Hodgson J, Ward N . The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers. Food Funct. 2017; 8(9):3366-3373. DOI: 10.1039/c7fo00926g. View

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K . Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006; 116(7):1784-92. PMC: 1483172. DOI: 10.1172/JCI29126. View

Lee W, Kim S . AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR Res. 2010; 2010. PMC: 2929615. DOI: 10.1155/2010/549101. View

Del Castillo M, Ames J, Gordon M . Effect of roasting on the antioxidant activity of coffee brews. J Agric Food Chem. 2002; 50(13):3698-703. DOI: 10.1021/jf011702q. View

Jung H, Im S, Song D, Bae J . Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells. BMB Rep. 2017; 50(6):323-328. PMC: 5498143. DOI: 10.5483/bmbrep.2017.50.6.182. View

Kappelmayer J, Nagy Jr B . The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression. Biomed Res Int. 2017; 2017:6138145. PMC: 5478826. DOI: 10.1155/2017/6138145. View

10.

Janani C, Kumari B . PPAR gamma gene--a review. Diabetes Metab Syndr. 2014; 9(1):46-50. DOI: 10.1016/j.dsx.2014.09.015. View

11.

Lee Y, Lee D, Kim J, Park M, Yan J, Song D . Lysophosphatidylcholine, oxidized low-density lipoprotein and cardiovascular disease in Korean hemodialysis patients: analysis at 5 years of follow-up. J Korean Med Sci. 2013; 28(2):268-73. PMC: 3565139. DOI: 10.3346/jkms.2013.28.2.268. View

12.

Zhao Y, Wang J, Ballevre O, Luo H, Zhang W . Antihypertensive effects and mechanisms of chlorogenic acids. Hypertens Res. 2011; 35(4):370-4. DOI: 10.1038/hr.2011.195. View

13.

Favero G, Paganelli C, Buffoli B, Rodella L, Rezzani R . Endothelium and its alterations in cardiovascular diseases: life style intervention. Biomed Res Int. 2014; 2014:801896. PMC: 3955677. DOI: 10.1155/2014/801896. View

14.

Oboh G, Agunloye O, Adefegha S, Akinyemi A, Ademiluyi A . Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study. J Basic Clin Physiol Pharmacol. 2014; 26(2):165-70. DOI: 10.1515/jbcpp-2013-0141. View

15.

Zang L, Cosma G, Gardner H, Castranova V, Vallyathan V . Effect of chlorogenic acid on hydroxyl radical. Mol Cell Biochem. 2003; 247(1-2):205-10. DOI: 10.1023/a:1024103428348. View

16.

Bobryshev Y, Ivanova E, Chistiakov D, Nikiforov N, Orekhov A . Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis. Biomed Res Int. 2016; 2016:9582430. PMC: 4967433. DOI: 10.1155/2016/9582430. View

17.

Renouf M, Guy P, Marmet C, Fraering A, Longet K, Moulin J . Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism. Mol Nutr Food Res. 2009; 54(6):760-6. DOI: 10.1002/mnfr.200900056. View

18.

Suzuki A, Nomura T, Jokura H, Kitamura N, Saiki A, Fujii A . Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study. Int J Food Sci Nutr. 2019; 70(7):901-908. DOI: 10.1080/09637486.2019.1585763. View

19.

Camare C, Pucelle M, Negre-Salvayre A, Salvayre R . Angiogenesis in the atherosclerotic plaque. Redox Biol. 2017; 12:18-34. PMC: 5312547. DOI: 10.1016/j.redox.2017.01.007. View

20.

Kim B, Lee D, Kim H, Park T, Kim J, Kim S . Bioactivity of Fermented Green Coffee Bean Extract Containing High Chlorogenic Acid and Surfactin. J Med Food. 2019; 22(3):305-313. DOI: 10.1089/jmf.2018.4262. View