Streptococcus Mutans Induces IgA Nephropathy-like Glomerulonephritis in Rats with Severe Dental Caries

Overview

Journal Sci Rep

Specialty Science

Date 2021 Mar 12

PMID 33707585

Citations 17

Authors

Shuhei Naka

Kaoruko Wato

Taro Misaki

Seigo Ito

Daiki Matsuoka

Yasuyuki Nagasawa

Ryota Nomura

Michiyo Matsumoto-Nakano

Kazuhiko Nakano

Affiliations

Soon will be listed here.

Abstract

The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S. mutans isolates that express Cnm protein on their cell surface were frequently detected in IgAN patients. In the present study, inoculation of Cnm-positive S. mutans in the oral cavities of 2-week-old specific-pathogen free Sprague-Dawley rats fed a high-sucrose diet for 32 weeks produced severe dental caries in all rats. Immunohistochemical analyses of the kidneys using IgA- and complement C3-specific antibodies revealed positive staining in the mesangial region. Scanning electron microscopy revealed a wide distribution of electron dense deposits in the mesangial region and periodic acid-Schiff staining demonstrated prominent proliferation of mesangial cells and mesangial matrix. These results suggest that IgAN-like glomerulonephritis was induced in rats with severe dental caries by Cnm-positive S. mutans.

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