Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver Disease

Overview

Journal Cell Mol Gastroenterol Hepatol

Specialty Gastroenterology

Date 2021 Mar 11

PMID 33705963

Citations 7

Authors

Tirthadipa Pradhan-Sundd

Shweta Gudapati

Tomasz W Kaminski

Margaret V Ragni

Affiliations

Soon will be listed here.

Abstract

Chronic liver disease is one of the leading causes of death in the United States. Coagulopathy is often a sequela of chronic liver disease, however, the role and regulation of coagulation components in chronic liver injury remain poorly understood. Clinical and experimental evidence indicate that misexpression of the procoagulant factor VIII (FVIII) is associated with chronic liver disease. Nevertheless, the molecular mechanism of FVIII-induced chronic liver injury progression remains unknown. This review provides evidence supporting a pathologic role for FVIII in the development of chronic liver disease using both experimental and clinical models.

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