Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/resistance by Increasing Adiponectin, Resistin, and Plasminogen Activator Inhibitor-I in Rats

Overview

Journal Turk J Med Sci

Specialty General Medicine

Date 2021 Mar 11

PMID 33705641

Citations 3

Authors

Cemil Kahraman

Huseyin Yaman

Affiliations

Soon will be listed here.

Abstract

Background/aim: Hyperbaric oxygen therapy (HBOT) causes insulin sensitivity, but the reason for this is not known yet. The aim of the present study was to investigate the effect of HBOT on insulin sensitivity via resistin, plasminogen activator inhibitor-I (PAI-I), and adiponectin.

Materials And Methods: The study was designed using HBOT and control groups, with eight rats in each group. After 20 days of HBOT under 2.5 atmospheres for 90 min, the fasting insulin (FI), resistin, PAI-I, homeostatic model assessment of insulin resistance scores (HOMA–IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), triglyceride, and high-density lipoprotein cholesterol (HDL-C) in the plasma were measured. The resistin, PAI-I, and adiponectin mRNA expression levels were also measured in the adipose tissue.

Results: Compared to the control group, the FI, FPG, and HOMA-IR scores were significantly lower in the HBOT group, whereas the HDL-C and QUICKI scores were found to be higher. In addition, the resistin, adiponectin, and PAI-I mRNA expression levels were also higher in the HBOT group.

Conclusion: The present study demonstrated that the HBOT had regulated the FI, FPG, and HDL-C associated with metabolic syndrome and diabetes mellitus. Moreover, the study showed that HBOT causes insulin sensitivity by raising adiponectin.

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References

Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray K, Thompson A . Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009; 302(18):1993-2000. PMC: 3284229. DOI: 10.1001/jama.2009.1619. View

Gordon T, CASTELLI W, Hjortland M, Kannel W, DAWBER T . High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977; 62(5):707-14. DOI: 10.1016/0002-9343(77)90874-9. View

Whitworth J, Williamson P, Brown M, Colman P . Hyperinsulinemia is not a cause of cortisol-induced hypertension. Am J Hypertens. 1994; 7(6):562-5. DOI: 10.1093/ajh/7.6.562. View

Alessi M, Peiretti F, Morange P, Henry M, Nalbone G, Juhan-Vague I . Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease. Diabetes. 1997; 46(5):860-7. DOI: 10.2337/diab.46.5.860. View

Gutch M, Kumar S, Razi S, Gupta K, Gupta A . Assessment of insulin sensitivity/resistance. Indian J Endocrinol Metab. 2015; 19(1):160-4. PMC: 4287763. DOI: 10.4103/2230-8210.146874. View

Bermudez V, Salazar J, Martinez M, Chavez-Castillo M, Olivar L, Calvo M . Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela. Adv Prev Med. 2016; 2016:9405105. PMC: 4989131. DOI: 10.1155/2016/9405105. View

Bhutani S, Vishwanath G . Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012; 45(2):316-24. PMC: 3495382. DOI: 10.4103/0970-0358.101309. View

Yasuda K, Adachi T, Gu N, Matsumoto A, Matsunaga T, Tsujimoto G . Effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels and skeletal muscle-fiber properties in diabetic rats. Muscle Nerve. 2006; 35(3):337-43. DOI: 10.1002/mus.20692. View

Liu Y, Zhang D, Yuan J, Song L, Zhang C, Lin Q . Hyperbaric Oxygen Ameliorates Insulin Sensitivity by Increasing GLUT4 Expression in Skeletal Muscle and Stimulating UCP1 in Brown Adipose Tissue in T2DM Mice. Front Endocrinol (Lausanne). 2020; 11:32. PMC: 7005601. DOI: 10.3389/fendo.2020.00032. View

10.

Marz W, Kleber M, Scharnagl H, Speer T, Zewinger S, Ritsch A . HDL cholesterol: reappraisal of its clinical relevance. Clin Res Cardiol. 2017; 106(9):663-675. PMC: 5565659. DOI: 10.1007/s00392-017-1106-1. View

11.

Ma L, Mao S, Taylor K, Kanjanabuch T, Guan Y, Zhang Y . Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes. 2004; 53(2):336-46. DOI: 10.2337/diabetes.53.2.336. View

12.

McMonnies C . Hyperbaric oxygen therapy and the possibility of ocular complications or contraindications. Clin Exp Optom. 2014; 98(2):122-5. DOI: 10.1111/cxo.12203. View

13.

Badimon J, Badimon L, Fuster V . Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest. 1990; 85(4):1234-41. PMC: 296557. DOI: 10.1172/JCI114558. View

14.

Wilkinson D, Chapman I, Heilbronn L . Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans. Diabet Med. 2012; 29(8):986-9. DOI: 10.1111/j.1464-5491.2012.03587.x. View

15.

Jamaluddin M, Weakley S, Yao Q, Chen C . Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2011; 165(3):622-32. PMC: 3315035. DOI: 10.1111/j.1476-5381.2011.01369.x. View

16.

Xu Q, Wei Y, Fan S, Wang L, Zhou X . Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage. Neuropsychiatr Dis Treat. 2017; 13:421-426. PMC: 5312693. DOI: 10.2147/NDT.S126288. View

17.

Wilkinson D, Nolting M, Mahadi M, Chapman I, Heilbronn L . Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with and without type 2 diabetes. Diving Hyperb Med. 2015; 45(1):30-6. View

18.

Kumar M, Radhika B, Gollamudi N, Reddy S, Yaga U . Hyperbaric Oxygen Therapy-A Novel Treatment Modality in Oral Submucous Fibrosis: A Review. J Clin Diagn Res. 2015; 9(5):ZE01-4. PMC: 4484182. DOI: 10.7860/JCDR/2015/11500.5905. View

19.

Lund V, Kentala E, Scheinin H, Klossner J, Koskinen P, Jalonen J . Effect of hyperbaric conditions on plasma stress hormone levels and endothelin-1. Undersea Hyperb Med. 1999; 26(2):87-92. View

20.

Berner J, Vidal P, Will P, Castillo P . [Use of hyperbaric oxygenation for wound management]. Rev Med Chil. 2015; 142(12):1575-83. DOI: 10.4067/S0034-98872014001200011. View