Equivalent Servings of Free-range Reindeer Promote Greater Net Protein Balance Compared to Commercial Beef

Overview

Journal Int J Circumpolar Health

Date 2021 Mar 11

PMID 33704030

Citations 1

Authors

Melynda S Coker

Scott E Schutzler

Sanghee Park

Rick H Williams

Arny A Ferrando

Nicolaas E P Deutz

Robert R Wolfe

Robert H Coker

Affiliations

Soon will be listed here.

Abstract

Wild game consumption has been associated with health benefits but the acute influence on human protein metabolism remains unknown. We compared feeding-induced responses of equivalent amounts of free-range reindeer (FR) and commercial beef (CB) on protein kinetics using stable isotope methodology. Seven participants (age: 40 ± 14 years; body mass index: 24 ± 3 kg/m) completed two randomised studies, ingesting 2 oz of FR or CB. L-[ring H]phenylalanine & L-[ring H]tyrosine were delivered via primed, continuous intravenous infusion. Blood samples were collected during the basal period and following consumption of FR or CB. Feeding-induced changes in whole-body protein synthesis (PS), protein breakdown (PB), and net protein balance (NB) were determined via plasma sample isotope enrichment analysis by gas chromatography-mass spectrometry; plasma essential amino acid (EAA) concentrations were determined by liquid chromatography-electrospray ionisation-mass spectrometry. Plasma post-prandial EAA concentrations were higher with FR compared to CB (P < 0.05). The acute feeding-induced PS response was not different, but PB was reduced and contributed to a superior level of NB (P < 0.00001) in FR compared to CB. Our results demonstrate that FR may influence more favourable protein metabolism than CB. These data support potential health benefits of wild game onf whole-body protein.Abbreviations: BMI: body mass index; DIAAS: digestible indispensable amino acid score; CB: commercial beef; EAA: essential amino acids; FR: free-range reindeer; R: rate of appearance; UAF: University of Alaska Fairbanks; USDA: USA Department of Agriculture.

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References

Kim I, Schutzler S, Schrader A, Spencer H, Kortebein P, Deutz N . Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults. Am J Physiol Endocrinol Metab. 2014; 308(1):E21-8. PMC: 4280213. DOI: 10.1152/ajpendo.00382.2014. View

Patel M, Sonesson U, Hessle A . Upgrading plant amino acids through cattle to improve the nutritional value for humans: effects of different production systems. Animal. 2016; 11(3):519-528. DOI: 10.1017/S1751731116001610. View

Henchion M, Hayes M, Mullen A, Fenelon M, Tiwari B . Future Protein Supply and Demand: Strategies and Factors Influencing a Sustainable Equilibrium. Foods. 2017; 6(7). PMC: 5532560. DOI: 10.3390/foods6070053. View

Sanada K, Chen R, Willcox B, Ohara T, Wen A, Takenaka C . Association of sarcopenic obesity predicted by anthropometric measurements and 24-y all-cause mortality in elderly men: The Kuakini Honolulu Heart Program. Nutrition. 2018; 46:97-102. DOI: 10.1016/j.nut.2017.09.003. View

Beaudart C, Rizzoli R, Bruyere O, Reginster J, Biver E . Sarcopenia: burden and challenges for public health. Arch Public Health. 2015; 72(1):45. PMC: 4373245. DOI: 10.1186/2049-3258-72-45. View

Goins R, Moss M, Buchwald D, Guralnik J . Disability among older American Indians and Alaska Natives: an analysis of the 2000 Census Public Use Microdata Sample. Gerontologist. 2007; 47(5):690-6. PMC: 3020595. DOI: 10.1093/geront/47.5.690. View

Abumrad N, Rabin D, Diamond M, LACY W . Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism. 1981; 30(9):936-40. DOI: 10.1016/0026-0495(81)90074-3. View

Wu G . Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. J Anim Sci Biotechnol. 2014; 5(1):34. PMC: 4082180. DOI: 10.1186/2049-1891-5-34. View

Borsheim E, Tipton K, Wolf S, Wolfe R . Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab. 2002; 283(4):E648-57. DOI: 10.1152/ajpendo.00466.2001. View

10.

Schure M, Goins R . An Examination of the Disablement Process Among Older American Indians: The Native Elder Care Study. Gerontologist. 2015; 56(5):948-55. PMC: 6080839. DOI: 10.1093/geront/gnv001. View

11.

Phang J, Liu W, Hancock C . Bridging epigenetics and metabolism: role of non-essential amino acids. Epigenetics. 2013; 8(3):231-6. PMC: 3669115. DOI: 10.4161/epi.24042. View

12.

DeBruyn L, Fullerton L, Satterfield D, Frank M . Integrating Culture and History to Promote Health and Help Prevent Type 2 Diabetes in American Indian/Alaska Native Communities: Traditional Foods Have Become a Way to Talk About Health. Prev Chronic Dis. 2020; 17:E12. PMC: 7021459. DOI: 10.5888/pcd17.190213. View

13.

Gerlach S, Loring P . Rebuilding northern foodsheds, sustainable food systems, community well-being, and food security. Int J Circumpolar Health. 2013; 72. PMC: 3748440. DOI: 10.3402/ijch.v72i0.21560. View

14.

Atawia R, Bunch K, Toque H, Caldwell R, Caldwell R . Mechanisms of obesity-induced metabolic and vascular dysfunctions. Front Biosci (Landmark Ed). 2019; 24(5):890-934. PMC: 6689231. DOI: 10.2741/4758. View

15.

Batal M, Johnson-Down L, Moubarac J, Ing A, Fediuk K, Sadik T . Quantifying associations of the dietary share of ultra-processed foods with overall diet quality in First Nations peoples in the Canadian provinces of British Columbia, Alberta, Manitoba and Ontario. Public Health Nutr. 2017; 21(1):103-113. PMC: 10260810. DOI: 10.1017/S1368980017001677. View

16.

Deane C, Ely I, Wilkinson D, Smith K, Phillips B, Atherton P . Dietary protein, exercise, ageing and physical inactivity: interactive influences on skeletal muscle proteostasis. Proc Nutr Soc. 2020; 80(2):106-117. DOI: 10.1017/S0029665120007879. View

17.

Moore D, Churchward-Venne T, Witard O, Breen L, Burd N, Tipton K . Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men. J Gerontol A Biol Sci Med Sci. 2014; 70(1):57-62. DOI: 10.1093/gerona/glu103. View

18.

Lavigne-Robichaud M, Moubarac J, Lantagne-Lopez S, Johnson-Down L, Batal M, Laouan Sidi E . Diet quality indices in relation to metabolic syndrome in an Indigenous Cree (Eeyouch) population in northern Québec, Canada. Public Health Nutr. 2017; 21(1):172-180. PMC: 10260753. DOI: 10.1017/S136898001700115X. View

19.

Hou Y, Yin Y, Wu G . Dietary essentiality of "nutritionally non-essential amino acids" for animals and humans. Exp Biol Med (Maywood). 2015; 240(8):997-1007. PMC: 4935284. DOI: 10.1177/1535370215587913. View

20.

Wolfe R, Park S, Kim I, Moughan P, Ferrando A . Advances in stable isotope tracer methodology part 2: new thoughts about an "old" method-measurement of whole body protein synthesis and breakdown in the fed state. J Investig Med. 2019; 68(1):11-15. DOI: 10.1136/jim-2019-001108. View