The Extracellular Matrix Regulates Cortical Layer Dynamics and Cross-columnar Frequency Integration in the Auditory Cortex

Overview

Journal Commun Biol

Specialty Biology

Date 2021 Mar 11

PMID 33692502

Citations 5

Authors

Mohamed El-Tabbal

Hartmut Niekisch

Julia U Henschke

Eike Budinger

Renato Frischknecht

Matthias Deliano

Max F K Happel

Affiliations

Soon will be listed here.

Abstract

In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. The impact of the ECM on translaminar dynamics during cortical circuit processing is still not understood. Here, we removed the ECM in the primary auditory cortex (ACx) of adult Mongolian gerbils using local injections of hyaluronidase (HYase). Using laminar current-source density (CSD) analysis, we found layer-specific changes of the spatiotemporal synaptic patterns with increased cross-columnar integration and simultaneous weakening of early local sensory input processing within infragranular layers Vb. These changes had an oscillatory fingerprint within beta-band (25-36 Hz) selectively within infragranular layers Vb. To understand the laminar interaction dynamics after ECM digestion, we used time-domain conditional Granger causality (GC) measures to identify the increased drive of supragranular layers towards deeper infragranular layers. These results showed that ECM degradation altered translaminar cortical network dynamics with a stronger supragranular lead of the columnar response profile.

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