A Novel Role of Hippo-Yap/TAZ Signaling Pathway in Lymphatic Vascular Development

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2021 Mar 11

PMID 33691907

Citations 5

Authors

Boksik Cha

Sungjin Moon

Wantae Kim

Affiliations

Soon will be listed here.

Abstract

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development. [BMB Reports 2021; 54(6): 285-294].

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References

Planas-Paz L, Strilic B, Goedecke A, Breier G, Fassler R, Lammert E . Mechanoinduction of lymph vessel expansion. EMBO J. 2011; 31(4):788-804. PMC: 3280555. DOI: 10.1038/emboj.2011.456. View

Petrova T, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D . Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med. 2004; 10(9):974-81. DOI: 10.1038/nm1094. View

Nonomura K, Lukacs V, Sweet D, Goddard L, Kanie A, Whitwam T . Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation. Proc Natl Acad Sci U S A. 2018; 115(50):12817-12822. PMC: 6294938. DOI: 10.1073/pnas.1817070115. View

Chen H, Griffin C, Xia L, Srinivasan R . Molecular and cellular mechanisms of lymphatic vascular maturation. Microvasc Res. 2014; 96:16-22. PMC: 4263685. DOI: 10.1016/j.mvr.2014.06.002. View

Semo J, Nicenboim J, Yaniv K . Development of the lymphatic system: new questions and paradigms. Development. 2016; 143(6):924-35. DOI: 10.1242/dev.132431. View

Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C . The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2005; 8(1):27-36. DOI: 10.1038/ncb1339. View

Wigle J, Oliver G . Prox1 function is required for the development of the murine lymphatic system. Cell. 1999; 98(6):769-78. DOI: 10.1016/s0092-8674(00)81511-1. View

Udan R, Kango-Singh M, Nolo R, Tao C, Halder G . Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol. 2003; 5(10):914-20. DOI: 10.1038/ncb1050. View

Tschaharganeh D, Chen X, Latzko P, Malz M, Gaida M, Felix K . Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology. 2013; 144(7):1530-1542.e12. PMC: 3665638. DOI: 10.1053/j.gastro.2013.02.009. View

10.

Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S . YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell. 2014; 158(1):157-70. DOI: 10.1016/j.cell.2014.06.013. View

11.

Choi H, Zhang H, Park H, Choi K, Lee H, Agrawal V . Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nat Commun. 2015; 6:6943. DOI: 10.1038/ncomms7943. View

12.

Srinivasan R, Escobedo N, Yang Y, Interiano A, Dillard M, Finkelstein D . The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014; 28(19):2175-87. PMC: 4180978. DOI: 10.1101/gad.216226.113. View

13.

Kim J, Kim Y, Kim J, Park D, Bae H, Lee D . YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017; 127(9):3441-3461. PMC: 5669570. DOI: 10.1172/JCI93825. View

14.

Ho Y, Srinivasan R . Lymphatic Vasculature in Energy Homeostasis and Obesity. Front Physiol. 2020; 11:3. PMC: 6987243. DOI: 10.3389/fphys.2020.00003. View

15.

Cha B, Geng X, Mahamud M, Zhang J, Chen L, Kim W . Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling. Cell Rep. 2018; 25(3):571-584.e5. PMC: 6264919. DOI: 10.1016/j.celrep.2018.09.049. View

16.

Bazigou E, Wilson J, Moore Jr J . Primary and secondary lymphatic valve development: molecular, functional and mechanical insights. Microvasc Res. 2014; 96:38-45. PMC: 4490164. DOI: 10.1016/j.mvr.2014.07.008. View

17.

Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen C, Tao C . The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol. 2006; 16(21):2090-100. DOI: 10.1016/j.cub.2006.09.005. View

18.

Sabine A, Bovay E, Saygili Demir C, Kimura W, Jaquet M, Agalarov Y . FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J Clin Invest. 2015; 125(10):3861-77. PMC: 4607114. DOI: 10.1172/JCI80454. View

19.

Justice R, Zilian O, Woods D, Noll M, Bryant P . The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 1995; 9(5):534-46. DOI: 10.1101/gad.9.5.534. View

20.

Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsater H . Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nat Commun. 2018; 9(1):1511. PMC: 5904183. DOI: 10.1038/s41467-018-03959-6. View