Selenium (Se) Plays a Key Role in the Biological Effects of Some Viruses: Implications for COVID-19

Overview

Journal Environ Res

Publisher Elsevier

Specialty Environmental Health

Date 2021 Mar 10

PMID 33691157

Citations 23

Authors

Qiyuan Liu

Xiaoli Zhao

Jin Ma

Yunsong Mu

Ying Wang

Shuhui Yang

Yihang Wu

Fengchang Wu

Yongzhang Zhou

Affiliations

Soon will be listed here.

Abstract

Host nutrition is an important factor affecting disease progression. Selenium (Se) is an essential trace element for the human body with anti-inflammatory, antioxidant, and immune effects, and Se deficiency increases RNA-virus replication and virulent mutations, which lead to more severe tissue damage and symptoms. Low Se status in the host may be an important cause of health complications induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this article, we describe the metabolic mechanisms by which Se is involved in anti-inflammatory, antioxidant, and immune effects, and review the role and clinical effects of Se in viral infection. We then discuss the potential relationship between Se and coronavirus disease 2019 (COVID-19). The association between soil Se level and the incidence of COVID-19 was observed in different cities of Hubei Province. The incidence of COVID-19 was more than 10 times lower in Se-enriched cities (Enshi, Shiyan, and Xiangyang) than in Se-deficient cities (Suizhou and Xiaogan). Although the relationship between soil Se levels and the incidence of COVID-19 in Hubei still needs further study, these findings provide baseline information demonstrating the effect of Se levels on SARS-CoV-2, which could contribute to the prevention and management of COVID-19.

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