Impact of Polycystic Ovary Syndrome on Quality of Life of Women in Correlation to Age, Basal Metabolic Index, Education and Marriage

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2021 Mar 10

PMID 33690645

Citations 16

Authors

Fauzia Tabassum

Chandra Jyoti

Hemali Heidi Sinha

Kavita Dhar

Md Sayeed Akhtar

Affiliations

Soon will be listed here.

Abstract

Polycystic ovary syndrome (PCOS) is the major endocrine related disorder in young age women. Physical appearance, menstrual irregularity as well as infertility are considered as a sole cause of mental distress affecting health-related quality of life (HRQOL). This prospective case-control study was conducted among 100 PCOS and 200 healthy control cases attending tertiary care set up of AIIMS, Patna during year 2017 and 2018. Pre-validated questionnaires like Short Form Health survey-36 were used for evaluating impact of PCOS in women. Multivariate analysis was applied for statistical analysis. In PCOS cases, socioeconomic status was comparable in comparison to healthy control. But, PCOS cases showed significantly decreased HRQOL. The higher age of menarche, irregular/delayed menstrual history, absence of child, were significantly altered in PCOS cases than control. Number of child, frequency of pregnancy, and miscarriage were also observed higher in PCOS cases. Furthermore, in various category of age, BMI, educational status and marital status, significant differences were observed in the different domain of SF-36 between PCOS and healthy control. Altogether, increased BMI, menstrual irregularities, educational status and marital status play a major role in altering HRQOL in PCOS cases and psychological care must be given during patient care.

Citing Articles

Reproductive Endocrine Disorders: A Comprehensive Guide to the Diagnosis and Management of Infertility, Polycystic Ovary Syndrome, and Endometriosis.

Saleem Azam S, Vasudevan S, Saqib Bukhari W, Thadhani J, Tasneem H, Singh S Cureus. 2025; 17(1):e78222.

PMID: 40027012 PMC: 11871525. DOI: 10.7759/cureus.78222.

Androgens and Hirsutism in a Large Cohort of Portuguese Women.

Pinto J, Cera N, Camerino C, Beires J, Pignatelli D J Clin Med. 2025; 14(3).

PMID: 39941345 PMC: 11818050. DOI: 10.3390/jcm14030673.

Canonical correlation analysis of family burden of disease and quality of life in caregivers of people living with schizophrenia: evidence from Schizophrenia-specific cohort in the less-developed multi-ethnic region of Southwest China.

Wang X, Zhang T, Li M, Yang B, Wang L, Fu C BMC Psychiatry. 2025; 25(1):1.

PMID: 39748412 PMC: 11697033. DOI: 10.1186/s12888-024-06458-9.

Prevalence of depression and anxiety in women with polycystic ovary syndrome (PCOS) and associated factors in a quaternary hospital in Thailand: a cross-sectional study.

Keeratibharat P, Sophonsritsuk A, Saipanish R, Wattanakrai P, Anantaburana M, Tantanavipas S BMC Psychiatry. 2024; 24(1):760.

PMID: 39487412 PMC: 11529037. DOI: 10.1186/s12888-024-06154-8.

Assessment of the Validity and Quality of Polycystic Ovarian Syndrome (PCOS) Screening Tools Available for Women Globally: A Systematic Review.

Sacca L, Lobaina D, Knopf E, Burgoa S, Jimenez S, Okwaraji G Clin Pract. 2024; 14(5):1625-1649.

PMID: 39311281 PMC: 11417729. DOI: 10.3390/clinpract14050131.

References

Lamb J, Johnstone E, Rousseau J, Jones C, Pasch L, Cedars M . Physical activity in women with polycystic ovary syndrome: prevalence, predictors, and positive health associations. Am J Obstet Gynecol. 2011; 204(4):352.e1-6. DOI: 10.1016/j.ajog.2010.12.006. View

Bottcher B, Fessler S, Friedl F, Toth B, Walter M, Wildt L . Health-related quality of life in patients with polycystic ovary syndrome: validation of the German PCOSQ-G. Arch Gynecol Obstet. 2017; 297(4):1027-1035. PMC: 5849657. DOI: 10.1007/s00404-017-4623-2. View

Kumarapeli V, Seneviratne R, Wijeyaratne C . Health-related quality of life and psychological distress in polycystic ovary syndrome: a hidden facet in South Asian women. BJOG. 2010; 118(3):319-28. DOI: 10.1111/j.1471-0528.2010.02799.x. View

Brazier J, Harper R, Jones N, OCathain A, Thomas K, Usherwood T . Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ. 1992; 305(6846):160-4. PMC: 1883187. DOI: 10.1136/bmj.305.6846.160. View

Behboodi Moghadam Z, Fereidooni B, Saffari M, Montazeri A . Measures of health-related quality of life in PCOS women: a systematic review. Int J Womens Health. 2018; 10:397-408. PMC: 6078086. DOI: 10.2147/IJWH.S165794. View

Li Y, Li Y, Ng E, Stener-Victorin E, Hou L, Wu T . Polycystic ovary syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from a meta-analysis. Fertil Steril. 2011; 96(2):452-8. DOI: 10.1016/j.fertnstert.2011.05.072. View

Okamura Y, Saito F, Takaishi K, Motohara T, Honda R, Ohba T . Polycystic ovary syndrome: early diagnosis and intervention are necessary for fertility preservation in young women with endometrial cancer under 35 years of age. Reprod Med Biol. 2017; 16(1):67-71. PMC: 5715875. DOI: 10.1002/rmb2.12012. View

Angin P, Yoldemir T, Atasayan K . Quality of life among infertile PCOS patients. Arch Gynecol Obstet. 2019; 300(2):461-467. DOI: 10.1007/s00404-019-05202-z. View

Yii M, Lim C, Luo X, Wong W, Cheng N, Zhan X . Polycystic ovarian syndrome in adolescence. Gynecol Endocrinol. 2009; 25(10):634-9. DOI: 10.1080/09513590903015551. View

10.

Di Fede G, Mansueto P, Longo R, Rini G, Carmina E . Influence of sociocultural factors on the ovulatory status of polycystic ovary syndrome. Fertil Steril. 2008; 91(5):1853-6. DOI: 10.1016/j.fertnstert.2008.02.161. View

11.

Micucci C, Valli D, Matacchione G, Catalano A . Current perspectives between metabolic syndrome and cancer. Oncotarget. 2016; 7(25):38959-38972. PMC: 5122443. DOI: 10.18632/oncotarget.8341. View

12.

Barnard L, Ferriday D, Guenther N, Strauss B, Balen A, Dye L . Quality of life and psychological well being in polycystic ovary syndrome. Hum Reprod. 2007; 22(8):2279-86. DOI: 10.1093/humrep/dem108. View

13.

Teede H, Deeks A, Moran L . Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010; 8:41. PMC: 2909929. DOI: 10.1186/1741-7015-8-41. View

14.

Cooney L, Dokras A . Beyond fertility: polycystic ovary syndrome and long-term health. Fertil Steril. 2018; 110(5):794-809. DOI: 10.1016/j.fertnstert.2018.08.021. View

15.

Escobar-Morreale H . Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018; 14(5):270-284. DOI: 10.1038/nrendo.2018.24. View

16.

Karimi M, Brazier J . Health, Health-Related Quality of Life, and Quality of Life: What is the Difference?. Pharmacoeconomics. 2016; 34(7):645-9. DOI: 10.1007/s40273-016-0389-9. View

17.

Mahalingaiah S, Diamanti-Kandarakis E . Targets to treat metabolic syndrome in polycystic ovary syndrome. Expert Opin Ther Targets. 2015; 19(11):1561-74. PMC: 4883581. DOI: 10.1517/14728222.2015.1101067. View

18.

Rowlands I, Teede H, Lucke J, Dobson A, Mishra G . Young women's psychological distress after a diagnosis of polycystic ovary syndrome or endometriosis. Hum Reprod. 2016; 31(9):2072-81. DOI: 10.1093/humrep/dew174. View

19.

. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004; 81(1):19-25. DOI: 10.1016/j.fertnstert.2003.10.004. View

20.

Shishehgar F, Ramezani Tehrani F, Mirmiran P, Hajian S, Baghestani A . Comparison of the Association of Excess Weight on Health Related Quality of Life of Women with Polycystic Ovary Syndrome: An Age- and BMI-Matched Case Control Study. PLoS One. 2016; 11(10):e0162911. PMC: 5063389. DOI: 10.1371/journal.pone.0162911. View