Mitochondrial Impairments in Aetiopathology of Multifactorial Diseases: Common Origin but Individual Outcomes in Context of 3P Medicine

Overview

Journal EPMA J

Date 2021 Mar 9

PMID 33686350

Citations 30

Authors

Lenka Koklesova

Marek Samec

Alena Liskova

Kevin Zhai

Dietrich Busselberg

Frank A Giordano

Peter Kubatka

Olga Golunitschaja

Affiliations

Soon will be listed here.

Abstract

Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a "vicious circle" characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies.

Citing Articles

Morphine sulfate nano-controlled release microspheres effectively relieve visceral pain caused by tumor in mice.

Zhou Y, Feng L Am J Transl Res. 2024; 16(9):4343-4354.

PMID: 39398570 PMC: 11470343. DOI: 10.62347/XVOZ6080.

Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions.

Li J, Sun W, Zhu X, Mei Y, Li W, Li J Metabolites. 2024; 14(6).

PMID: 38921477 PMC: 11205546. DOI: 10.3390/metabo14060343.

: a review in the context of PPPM approach.

Xu W, Yang T, Zhang J, Li H, Guo M EPMA J. 2024; 15(2):233-259.

PMID: 38841616 PMC: 11147995. DOI: 10.1007/s13167-024-00367-3.

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID.

Naidu A, Wang C, Rao P, Mancini F, Clemens R, Wirakartakusumah A NPJ Sci Food. 2024; 8(1):19.

PMID: 38555403 PMC: 10981760. DOI: 10.1038/s41538-024-00261-2.

In pre-clinical study fetal hypoxia caused autophagy and mitochondrial impairment in ovary granulosa cells mitigated by melatonin supplement.

Zhang L, Liu K, Liu Z, Tao H, Fu X, Hou J J Adv Res. 2023; 64:15-30.

PMID: 37956860 PMC: 11464463. DOI: 10.1016/j.jare.2023.11.008.

References

Toraih E, Alrefai H, Hussein M, Helal G, Khashana M, Fawzy M . Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study. Clin Biochem. 2018; 63:10-17. DOI: 10.1016/j.clinbiochem.2018.12.001. View

Zhang P, Liu B . Association between Parkinson's Disease and Risk of Cancer: A PRISMA-compliant Meta-analysis. ACS Chem Neurosci. 2019; 10(10):4430-4439. DOI: 10.1021/acschemneuro.9b00498. View

Pavlov P, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B . Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J. 2010; 25(1):78-88. DOI: 10.1096/fj.10-157230. View

Meijers W, de Boer R . Common risk factors for heart failure and cancer. Cardiovasc Res. 2019; 115(5):844-853. PMC: 6452432. DOI: 10.1093/cvr/cvz035. View

Polivka Jr J, Polivka J, Pesta M, Rohan V, Celedova L, Mahajani S . Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach. EPMA J. 2019; 10(1):81-99. PMC: 6459458. DOI: 10.1007/s13167-019-00162-5. View

Borsche M, Pereira S, Klein C, Grunewald A . Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects. J Parkinsons Dis. 2020; 11(1):45-60. PMC: 7990451. DOI: 10.3233/JPD-201981. View

Munzar M, Levy S, Rush R, Averback P . Clinical study of a urinary competitve ELISA for neural thread protein in Alzheimer disease. Neurol Clin Neurophysiol. 2002; 2002(1):2-8. DOI: 10.1162/15268740252769709. View

Brandon M, Baldi P, Wallace D . Mitochondrial mutations in cancer. Oncogene. 2006; 25(34):4647-62. DOI: 10.1038/sj.onc.1209607. View

Perez M, Jara C, Quintanilla R . Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration. Front Neurosci. 2018; 12:441. PMC: 6041396. DOI: 10.3389/fnins.2018.00441. View

10.

Golubnitschaja O, Flammer J . What are the biomarkers for glaucoma?. Surv Ophthalmol. 2007; 52 Suppl 2:S155-61. DOI: 10.1016/j.survophthal.2007.08.011. View

11.

Roth G, Johnson C, Abajobir A, Abd-Allah F, Abera S, Abyu G . Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. J Am Coll Cardiol. 2017; 70(1):1-25. PMC: 5491406. DOI: 10.1016/j.jacc.2017.04.052. View

12.

Cairns R, Mak T . Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov. 2013; 3(7):730-41. DOI: 10.1158/2159-8290.CD-13-0083. View

13.

Webster K . Mitochondrial Death Channels. Am Sci. 2011; 97(5):384-391. PMC: 3163465. DOI: 10.1511/2009.80.384. View

14.

Carew J, Huang P . Mitochondrial defects in cancer. Mol Cancer. 2003; 1:9. PMC: 149412. DOI: 10.1186/1476-4598-1-9. View

15.

Durcan T, Fon E . The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Genes Dev. 2015; 29(10):989-99. PMC: 4441056. DOI: 10.1101/gad.262758.115. View

16.

Chaari L, Golubnitschaja O . Covid-19 pandemic by the "real-time" monitoring: the Tunisian case and lessons for global epidemics in the context of 3PM strategies. EPMA J. 2020; 11(2):133-138. PMC: 7182506. DOI: 10.1007/s13167-020-00207-0. View

17.

Kuznetsov A, Janakiraman M, Margreiter R, Troppmair J . Regulating cell survival by controlling cellular energy production: novel functions for ancient signaling pathways?. FEBS Lett. 2004; 577(1-2):1-4. DOI: 10.1016/j.febslet.2004.10.021. View

18.

Wang L, Shen C, Wang Y, Zou T, Zhu H, Lu X . Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease. Atherosclerosis. 2019; 286:88-96. DOI: 10.1016/j.atherosclerosis.2019.05.006. View

19.

Podlesniy P, Figueiro-Silva J, Llado A, Antonell A, Sanchez-Valle R, Alcolea D . Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease. Ann Neurol. 2013; 74(5):655-68. DOI: 10.1002/ana.23955. View

20.

Smith A, Depp C, Ryan B, Johnston G, Alegre-Abarrategui J, Evetts S . Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells. Mov Disord. 2018; 33(10):1580-1590. PMC: 6221131. DOI: 10.1002/mds.104. View