Bioinformatics Analysis of Myelin Transcription Factor 1

Overview

Journal Technol Health Care

Publisher Sage Publications

Specialties Biomedical Engineering
Biotechnology
Health Services

Date 2021 Mar 8

PMID 33682781

Citations 2

Authors

Hongjun Ding

Yanju Li

Yanlong Zhang

Huipeng Meng

Keqiang Wang

Qian Sun

Xichuan Li

Huajiang Dong

Long Chen

Feng He

Affiliations

Soon will be listed here.

Abstract

Background And Objective: We aimed to further study the role of Myelin Transcription Factor 1(MyT1) in tumor and other diseases and epigenetic regulation, and better understand the regulatory mechanism of MyT1.

Methods: Using bioinformatics analysis, the structure and function of MyT1sequence were predicted and analyzed using bioinformatics analysis, and providing a theoretical basis for further experimental verification and understanding the regulatory mechanism of MyT1. The first, second and third-level structures of MyT1 were predicted and analyzed by bioinformatics analysis tools.

Results: MyT1 is found to be an unstable hydrophilic protein, rather than a secretory protein, with no signal peptide or trans-membrane domain; total amino acids located on the surface of the cell membrane. It contains seven zinc finger domains structurally. At sub-cellular level, MyT1 is localized in the nucleus. The phosphorylation site mainly exists in serine, and its secondary structure is mainly composed of random coils and alpha helices; the three-dimensional structure is analyzed by modeling.

Conclusions: In this study, the structure and function of MyT1 protein were predicted, thereby providing a basis for subsequent expression analysis and functional research; it laid the foundation for further investigation of the molecular mechanism involved in the development of diseases.

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