The Latest Overview of CircRNA in the Progression, Diagnosis, Prognosis, Treatment, and Drug Resistance of Hepatocellular Carcinoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Mar 8

PMID 33680930

Citations 14

Authors

Dandan Xiong

Rongquan He

Yiwu Dang

Huayu Wu

Zhenbo Feng

Gang Chen

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is one of the main causes of tumor-related deaths worldwide. Due to the lack of obvious early symptoms and the lack of sensitive screening indicators in the early stage of HCC, the vast majority of patients are diagnosed with advanced or metastatic HCC, resulting in dissatisfactory treatment result. Therefore, it is urgent to determine effective and sensitive diagnostic and prognostic indicators and to determine new therapeutic targets. Circular RNA (circRNA) is a type of non-coding RNA that has been neglected for a long time. In recent years, it has been proved to play an important role in the development of many human diseases. Increasing evidence shows that change in circRNA expression has an extensive effect on the biological behavior of HCC. In this study, we comprehensively tracked the latest progress of circRNA in the pathogenesis of HCC, and reviewed its role as a biomarker for diagnosis and prognosis prediction in patients with HCC. In addition, we also summarized the potential of circRNA as therapeutic target in HCC and its relationship with HCC drug resistance, providing clues for the clinical development of circRNA-based therapeutic strategies.

Citing Articles

A Comprehensive Insight and In Silico Analysis of CircRNAs in Hepatocellular Carcinoma: A Step toward ncRNA-Based Precision Medicine.

Youness R, Hassan H, Abaza T, Hady A, El Magdoub H, Ali M Cells. 2024; 13(15.

PMID: 39120276 PMC: 11312109. DOI: 10.3390/cells13151245.

Circ_0007386 Promotes the Progression of Hepatocellular Carcinoma Through the miR-507/ CCNT2 Axis.

Feng Y, Liang L, Jia W, Wang J, Xu C, Zhu D J Hepatocell Carcinoma. 2024; 11:1095-1112.

PMID: 38887684 PMC: 11182359. DOI: 10.2147/JHC.S459633.

Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis.

Tian Y, Zhang M, Liu L, Wang Z, Liu B, Huang Y Front Immunol. 2024; 15:1400744.

PMID: 38799446 PMC: 11116607. DOI: 10.3389/fimmu.2024.1400744.

Advanced approaches of the use of circRNAs as a replacement for cancer therapy.

Faraj G, Hussen B, Abdullah S, Rasul M, Hajiesmaeili Y, Baniahmad A Noncoding RNA Res. 2024; 9(3):811-830.

PMID: 38590433 PMC: 10999493. DOI: 10.1016/j.ncrna.2024.03.012.

Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.

Liu Y, Dong Z, Chen W, Chen L, Ju L, Cai W Sci Rep. 2023; 13(1):22058.

PMID: 38086834 PMC: 10716167. DOI: 10.1038/s41598-023-47374-4.

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