Distortion of Micronuclei and Other Peripheral Erythrocytes Caused by Fenitrothion and Their Recovery Assemblage in Zebrafish

Overview

Journal Toxicol Rep

Date 2021 Mar 8

PMID 33680864

Citations 7

Authors

Mt Marufa Khatun

Golam Mohammod Mostakim

Md Moniruzzaman

Umme Ohida Rahman

M Sadiqul Islam

Affiliations

Soon will be listed here.

Abstract

The experiment was explicated to investigate the fenitrothion persuaded genotoxicity in the peripheral erythrocytes of zebrafish () through exposures (10 %, 20 % and 40 % of LC of fenitrothion, i.e., 0.8, 1.6, and 3.2 mg/L, respectively) for variable periods (1, 3, and 7 days) and its subsequent post-exposure recuperation array in pesticide-free water for similar intervals was also evaluated. With the exception of the control group (0% of fenitrothion), the obtained results pointed out that with the promotion of time and concentrations, fenitrothion induced significantly ( < 0.05) higher prevalence and severity of erythrocytic nuclear abnormalities (ENA) such as- notched, micronucleus, nuclear bridges, blebbed, binucleated, nuclear bud and also erythrocytic cellular abnormalities ECA) such as - echinocytic, elongated, tear-drop, crescentic, twin, fusion, and spindle-shaped cells. Recuperation data stated that zebrafish cured spontaneously and aberrated erythrocytic anomalies in all treatments were renormalized according to the concentration and duration dependence. Hence, we concluded that fenitrothion has a dangerous effect on the zebrafish, and this technology can be used to anticipate the sensitivity of aquatic animals to environmental pollution.

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