Malignant and Benign Thyroid Nodule Differentiation Through the Analysis of Blood Plasma with Terahertz Spectroscopy

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2021 Mar 8

PMID 33680557

Citations 6

Authors

Maria R Konnikova

Olga P Cherkasova

Maxim M Nazarov

Denis A Vrazhnov

Yuri V Kistenev

Sergei E Titov

Elena V Kopeikina

Sergei P Shevchenko

Alexander P Shkurinov

Affiliations

Soon will be listed here.

Abstract

The liquid and lyophilized blood plasma of patients with benign or malignant thyroid nodules and healthy individuals were studied by terahertz (THz) time-domain spectroscopy and machine learning. The blood plasma samples from malignant nodule patients were shown to have higher absorption. The glucose concentration and miRNA-146b level were correlated with the sample's absorption at 1 THz. A two-stage ensemble algorithm was proposed for the THz spectra analysis. The first stage was based on the Support Vector Machine with a linear kernel to separate healthy and thyroid nodule participants. The second stage included additional data preprocessing by Ornstein-Uhlenbeck kernel Principal Component Analysis to separate benign and malignant thyroid nodule participants. Thus, the distinction of malignant and benign thyroid nodule patients through their lyophilized blood plasma analysis by terahertz time-domain spectroscopy and machine learning was demonstrated.

Citing Articles

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References

Matrone A, Campopiano M, Nervo A, Sapuppo G, Tavarelli M, De Leo S . Differentiated Thyroid Cancer, From Active Surveillance to Advanced Therapy: Toward a Personalized Medicine. Front Endocrinol (Lausanne). 2020; 10:884. PMC: 6961292. DOI: 10.3389/fendo.2019.00884. View

Reid C, Reese G, Gibson A, Wallace V . Terahertz time-domain spectroscopy of human blood. IEEE J Biomed Health Inform. 2014; 17(4):774-8. DOI: 10.1109/JBHI.2013.2255306. View

Danciu M, Alexa-Stratulat T, Stefanescu C, Dodi G, Tamba B, Mihai C . Terahertz Spectroscopy and Imaging: A Cutting-Edge Method for Diagnosing Digestive Cancers. Materials (Basel). 2019; 12(9). PMC: 6539301. DOI: 10.3390/ma12091519. View

Shibru D, Chung K, Kebebew E . Recent developments in the clinical application of thyroid cancer biomarkers. Curr Opin Oncol. 2007; 20(1):13-8. DOI: 10.1097/CCO.0b013e3282f27e49. View

Khatami F, Payab M, Sarvari M, Gilany K, Larijani B, Arjmand B . Oncometabolites as biomarkers in thyroid cancer: a systematic review. Cancer Manag Res. 2019; 11:1829-1841. PMC: 6395057. DOI: 10.2147/CMAR.S188661. View

Liu H, Zhao K, Liu X, Zhang Z, Qian J, Zhang C . Diagnosis of hepatocellular carcinoma based on a terahertz signal and VMD-CWSE. Biomed Opt Express. 2020; 11(9):5045-5059. PMC: 7510877. DOI: 10.1364/BOE.392860. View

Jeong K, Huh Y, Kim S, Park Y, Son J, Oh S . Characterization of blood using terahertz waves. J Biomed Opt. 2013; 18(10):107008. DOI: 10.1117/1.JBO.18.10.107008. View

Sun C, Chen H, Tseng T, You B, Wei M, Lu J . High Sensitivity of T-Ray for Thrombus Sensing. Sci Rep. 2018; 8(1):3948. PMC: 5834502. DOI: 10.1038/s41598-018-22060-y. View

Gavdush A, Chernomyrdin N, Malakhov K, Beshplav S, Dolganova I, Kosyrkova A . Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis. J Biomed Opt. 2019; 24(2):1-5. PMC: 6988181. DOI: 10.1117/1.JBO.24.2.027001. View

10.

Tseng T, You B, Gao H, Wang T, Sun C . Pilot clinical study to investigate the human whole blood spectrum characteristics in the sub-THz region. Opt Express. 2015; 23(7):9440-51. DOI: 10.1364/OE.23.009440. View

11.

Depciuch J, Stanek-Widera A, Skrzypiec D, Lange D, Biskup-Fruzynska M, Kiper K . Spectroscopic identification of benign (follicular adenoma) and cancerous lesions (follicular thyroid carcinoma) in thyroid tissues. J Pharm Biomed Anal. 2019; 170:321-326. DOI: 10.1016/j.jpba.2019.03.061. View

12.

Wong C, Liu X, Lang B . Cost-effectiveness of fine-needle aspiration cytology (FNAC) and watchful observation for incidental thyroid nodules. J Endocrinol Invest. 2020; 43(11):1645-1654. DOI: 10.1007/s40618-020-01254-0. View

13.

Sciacchitano S, Lavra L, Ulivieri A, Magi F, De Francesco G, Bellotti C . Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology. Oncotarget. 2017; 8(30):49421-49442. PMC: 5564779. DOI: 10.18632/oncotarget.17220. View

14.

Wojtowicz W, Zabek A, Deja S, Dawiskiba T, Pawelka D, Glod M . Serum and urine H NMR-based metabolomics in the diagnosis of selected thyroid diseases. Sci Rep. 2017; 7(1):9108. PMC: 5567318. DOI: 10.1038/s41598-017-09203-3. View

15.

Xu L, Gao J, Wang Q, Yin J, Yu P, Bai B . Computer-Aided Diagnosis Systems in Diagnosing Malignant Thyroid Nodules on Ultrasonography: A Systematic Review and Meta-Analysis. Eur Thyroid J. 2020; 9(4):186-193. PMC: 7445671. DOI: 10.1159/000504390. View

16.

Ohtake S, Kita Y, Arakawa T . Interactions of formulation excipients with proteins in solution and in the dried state. Adv Drug Deliv Rev. 2011; 63(13):1053-73. DOI: 10.1016/j.addr.2011.06.011. View

17.

Kang T, Kim D, Lee Y, Cho Y, Jung S, Park H . Magnetic Resonance Imaging Features of Normal Thyroid Parenchyma and Incidental Diffuse Thyroid Disease: A Single-Center Study. Front Endocrinol (Lausanne). 2018; 9:746. PMC: 6291476. DOI: 10.3389/fendo.2018.00746. View

18.

Kim D, Song K, Kim S . High prevalence of carcinoma in ultrasonography-guided fine needle aspiration cytology of thyroid nodules. Endocr J. 2008; 55(1):135-42. DOI: 10.1507/endocrj.k07-120. View

19.

Taylor J, Mochizuki K, Hashimoto K, Kumamoto Y, Harada Y, Fujita K . High-Resolution Raman Microscopic Detection of Follicular Thyroid Cancer Cells with Unsupervised Machine Learning. J Phys Chem B. 2019; 123(20):4358-4372. DOI: 10.1021/acs.jpcb.9b01159. View

20.

Treglia G, Kroiss A, Piccardo A, Lococo F, Santhanam P, Imperiale A . Role of positron emission tomography in thyroid and neuroendocrine tumors. Minerva Endocrinol. 2017; 43(3):341-355. DOI: 10.23736/S0391-1977.17.02742-0. View