Good's Syndrome with a Relapsed Bloodstream Infection Induced by Sp. After Thymectomy: A Case Report

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2021 Mar 8

PMID 33680121

Authors

Sumei Chen

Jiangfu Liu

Yongnian Lin

Yipeng Gao

Affiliations

Soon will be listed here.

Abstract

Good's syndrome (GS) or thymoma-associated immunodeficiency is a rare clinical syndrome with poor prognosis. The varied and unspecified clinical manifestations of GS commonly lead to a missed or delayed diagnosis. Thus, misdiagnosis and missed diagnosis are common. The present case study reports on a patient who suffered from a relapsed bloodstream infection caused by sp. 6 months after thymectomy. The patient was finally diagnosed with GS after analyzing the clinical features and detecting T-lymphocyte subsets in the peripheral blood and humoral immune function. The patient's condition improved after anti-infection treatment and supplementation with intravenous immunoglobulin. Furthermore, no infection was observed during the 1-year follow-up.

References

Ohuchi M, Inoue S, Hanaoka J, Igarashi T, Tezuka N, Ozaki Y . Good syndrome coexisting with leukopenia. Ann Thorac Surg. 2007; 84(6):2095-7. DOI: 10.1016/j.athoracsur.2007.06.070. View

Idress A, Wahla A . Good syndrome, a rare disease that physicians cannot afford to overlook; case report and review of literature. J Pak Med Assoc. 2014; 63(12):1541-3. View

Kaufman A, Palatt J, Sivak M, Raimondi P, Lee D, Wolf A . Thymectomy for Myasthenia Gravis: Complete Stable Remission and Associated Prognostic Factors in Over 1000 Cases. Semin Thorac Cardiovasc Surg. 2017; 28(2):561-568. DOI: 10.1053/j.semtcvs.2016.04.002. View

Kelleher P, Misbah S . What is Good's syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol. 2002; 56(1):12-6. PMC: 1769851. DOI: 10.1136/jcp.56.1.12. View

Joven M, Palalay M, Sonido C . Case report and literature review on Good's syndrome, a form of acquired immunodeficiency associated with thymomas. Hawaii J Med Public Health. 2013; 72(2):56-62. PMC: 3585500. View

Stark J . Alcaligenes xylosoxidans osteomyelitis without trauma in a patient with Good's syndrome. Eur J Intern Med. 2007; 18(5):447. DOI: 10.1016/j.ejim.2007.02.007. View

Tarr P, Sneller M, Mechanic L, Economides A, Eger C, Strober W . Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature. Medicine (Baltimore). 2001; 80(2):123-33. DOI: 10.1097/00005792-200103000-00005. View

GOOD R . Absence of plasma cells from bone marrow and lymph nodes following antigenic stimulation in patients with a gamma globulinemia. Rev Hematol. 1954; 9(3 bis):502-3. View

Kelesidis T, Yang O . Good's syndrome remains a mystery after 55 years: A systematic review of the scientific evidence. Clin Immunol. 2010; 135(3):347-63. PMC: 8071094. DOI: 10.1016/j.clim.2010.01.006. View

10.

Chen X, Zhang J, Shang W, Xie W, Jin S, Wang F . Aberrant Peripheral Immune Function in a Good Syndrome Patient. J Immunol Res. 2018; 2018:6212410. PMC: 5937423. DOI: 10.1155/2018/6212410. View

11.

Thongngarm T, Boonyasiri A, Pradubpongsa P, Tesavibul N, Anekpuritanang T, Kreetapirom P . Features and outcomes of immunoglobulin therapy in patients with Good syndrome at Thailand's largest tertiary referral hospital. Asian Pac J Allergy Immunol. 2018; 37(2):109-115. DOI: 10.12932/AP-131117-0196. View

12.

Tavakol M, Mahdaviani S, Ghaemi M, Vaezi M, Dorudinia A, Jamaati H . Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report. Iran J Allergy Asthma Immunol. 2018; 17(1):85-93. View

13.

Zaman M, Huissoon A, Buckland M, Patel S, Alachkar H, Edgar J . Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia). Clin Exp Immunol. 2018; 195(1):132-138. PMC: 6300645. DOI: 10.1111/cei.13216. View

14.

Bernard C, Frih H, Pasquet F, Kerever S, Jamilloux Y, Tronc F . Thymoma associated with autoimmune diseases: 85 cases and literature review. Autoimmun Rev. 2015; 15(1):82-92. DOI: 10.1016/j.autrev.2015.09.005. View

15.

Health Commission Of The Peoples Republic Of China N . Protocol for Prevention and Control of COVID-19 (Edition 6). China CDC Wkly. 2021; 2(19):321-326. PMC: 8392946. DOI: 10.46234/ccdcw2020.082. View

16.

Dong J, Gao W, Teng G, Tian Y, Wang H . Characteristics of Good's Syndrome in China: A Systematic Review. Chin Med J (Engl). 2017; 130(13):1604-1609. PMC: 5494925. DOI: 10.4103/0366-6999.208234. View