Association of Serum Chemerin with Calcium, Alkaline Phosphatase and Bone Mineral Density in Postmenopausal Females

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2021 Mar 8

PMID 33679918

Citations 6

Authors

Saba Tariq

Sundus Tariq

Muhammad Shahzad

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate the association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal non-osteoporotic and osteoporotic females.

Methods: This cross-section analysis was carried out at the orthopedic department of Madina Teaching Hospital, Faisalabad, Pakistan, in the year 2017-2019. Postmenopausal females were divided into two groups according to their bone mineral density (BMD). All osteoporotic females had a T-score of -2.5 or less. Data were analyzed on SPSS-24.

Results: A total of 140 women were included in our study (80 osteoporotic and 60 non-osteoporotic). Non significant difference in age and BMI was observed between osteoporotic and non-osteoporotic subjects (p=0.152) and (p=0.291) respectively. There was a significant difference found in total BMD, serum chemerin levels between osteoporotic and non-osteoporotic subjects p<0.001 in both parameters. No significant correlation of serum chemerin was found with serum calcium, serum alkaline phosphatase and BMD in postmenopausal osteoporotic females (p=0.907), (p=0.318) (p=0.664) respectively. A significant negative correlation was found between serum alkaline phosphatase levels and total BMD in postmenopausal osteoporotic females (p=- 0.039). Linear regression analysis of serum alkaline phosphatase levels with total BMD showed no association between BMD and serum alkaline phosphatase levels (p=0.869).

Conclusion: There is no association of serum chemerin with calcium, ALP and bone mineral density in non-osteoporotic and osteoporotic postmenopausal females.

Citing Articles

Bridging the Gap: A narrative review of osteoporosis disability, adipokines, and the role of AI in postmenopausal women.

Tariq S, Jabbar S, Ahmad A, Tariq S Pak J Med Sci. 2024; 40(7):1572-1577.

PMID: 39092029 PMC: 11255809. DOI: 10.12669/pjms.40.7.9072.

Editorial: Osteoporosis and adipokines: the potential for future treatment.

Tariq S, Tariq S, Baig M, Valjevac A Front Endocrinol (Lausanne). 2024; 15:1405412.

PMID: 38660520 PMC: 11039904. DOI: 10.3389/fendo.2024.1405412.

A diagnostic approach integrated multimodal radiomics with machine learning models based on lumbar spine CT and X-ray for osteoporosis.

Liwei Cheng , Cai F, Xu M, Liu P, Liao J, Zong S J Bone Miner Metab. 2023; 41(6):877-889.

PMID: 37898574 DOI: 10.1007/s00774-023-01469-0.

Application of bone alkaline phosphatase and 25-oxhydryl-vitamin D in diagnosis and prediction of osteoporotic vertebral compression fractures.

Chen Y, Sun X, Sui X, Li Y, Wang Z J Orthop Surg Res. 2023; 18(1):739.

PMID: 37775805 PMC: 10543335. DOI: 10.1186/s13018-023-04144-2.

Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females.

Tariq S, Tariq S, Khaliq S, Abualhamael S, Baig M Front Endocrinol (Lausanne). 2022; 13:1024860.

PMID: 36531488 PMC: 9748547. DOI: 10.3389/fendo.2022.1024860.

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