Immunological Impact of Intestinal T Cells on Metabolic Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Mar 8

PMID 33679800

Citations 6

Authors

Haiyan Zhou

Liwen Wang

Feng Liu

Affiliations

Soon will be listed here.

Abstract

Emerging evidence accumulated over the past several years has uncovered intestinal CD4 T cells as an essential mediator in modulating intestinal immunity in health and diseases. It has also been increasingly recognized that dietary and microbiota-derived factors play key roles in shaping the intestinal CD4 T-cell compartment. This review aims to discuss the current understanding on how the intestinal T cell immune responses are disturbed by obesity and metabolic stress. In addition, we review how these changes influence systemic metabolic homeostasis and the T-cell-mediated crosstalk between gut and liver or brain in the progression of obesity and its related diseases. Lastly, we highlight the potential roles of some drugs that target intestinal T cells as a therapeutic treatment for metabolic diseases. A better understanding of the interaction among metabolites, bacterial signals, and T cell immune responses in the gut and their roles in systemic inflammation in metabolic tissues should shed new light on the development of effective treatment of obesity and related disorders.

Citing Articles

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