Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Mar 8

PMID 33679732

Citations 39

Authors

Rui Zhao

Wei Zhang

Chenghong Ma

Yaping Zhao

Rong Xiong

Hanmin Wang

Weiwen Chen

Song Guo Zheng

Affiliations

Soon will be listed here.

Abstract

Vitamin D is one of the most important nutrients required by the human body. It is a steroid hormone that plays an important role in regulating calcium and phosphorus metabolism, and bone health. Epidemiological studies have revealed a close correlation between vitamin D and many common chronic diseases. Additionally, vitamin D has recently been shown to act as an immunomodulatory hormone, and, accordingly, vitamin D deficiency was uncovered as a risk factor for autoimmune thyroid diseases, although the underlying mechanisms are still unknown. It is therefore necessary to disclose the role and mechanism of action of vitamin D in the occurrence and development of autoimmune thyroid diseases. This knowledge will help design intervention and early treatment strategies for patients with autoimmune thyroid diseases who present with low levels of vitamin D.

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References

Nettore I, Albano L, Ungaro P, Colao A, Macchia P . Sunshine vitamin and thyroid. Rev Endocr Metab Disord. 2017; 18(3):347-354. PMC: 5543192. DOI: 10.1007/s11154-017-9406-3. View

Bishop E, Ismailova A, Dimeloe S, Hewison M, White J . Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti-Inflammatory. JBMR Plus. 2020; 5(1):e10405. PMC: 7461279. DOI: 10.1002/jbm4.10405. View

Kim D . The Role of Vitamin D in Thyroid Diseases. Int J Mol Sci. 2017; 18(9). PMC: 5618598. DOI: 10.3390/ijms18091949. View

Xiao Z, Zheng X, Hu L, Wang J, Olsen N, Zheng S . Immunosuppressive Effect of B7-H4 Pathway in a Murine Systemic Lupus Erythematosus Model. Front Immunol. 2018; 8:1765. PMC: 5732181. DOI: 10.3389/fimmu.2017.01765. View

Zhang Q, Wang Z, Sun M, Cao M, Zhu Z, Fu Q . Association of high vitamin d status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. Int J Endocrinol. 2014; 2014:631819. PMC: 3947886. DOI: 10.1155/2014/631819. View

Djeraba Z, Benlabidi F, Djaballah-Ider F, Medjeber O, Arroul-Lammali A, Belguendouz H . Vitamin D status in Algerian Behçet's disease patients: an immunomodulatory effect on NO pathway. Immunopharmacol Immunotoxicol. 2017; 39(4):243-250. DOI: 10.1080/08923973.2017.1327967. View

Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J . Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006; 36(2):361-70. DOI: 10.1002/eji.200425995. View

Chen W, Wang J, Xu Z, Huang F, Qian W, Ma J . Apremilast Ameliorates Experimental Arthritis Suppression of Th1 and Th17 Cells and Enhancement of CD4Foxp3 Regulatory T Cells Differentiation. Front Immunol. 2018; 9:1662. PMC: 6058600. DOI: 10.3389/fimmu.2018.01662. View

Cho Y, Chung Y . Vitamin D supplementation does not prevent the recurrence of Graves' disease. Sci Rep. 2020; 10(1):16. PMC: 6949266. DOI: 10.1038/s41598-019-55107-9. View

10.

Kundu R, Theodoraki A, Haas C, Zhang Y, Chain B, Kriston-Vizi J . Cell-type-specific modulation of innate immune signalling by vitamin D in human mononuclear phagocytes. Immunology. 2016; 150(1):55-63. PMC: 5167305. DOI: 10.1111/imm.12669. View

11.

Bellan M, Andreoli L, Mele C, Sainaghi P, Rigamonti C, Piantoni S . Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases. Nutrients. 2020; 12(3). PMC: 7146294. DOI: 10.3390/nu12030789. View

12.

Zhang H, Liang L, Xie Z . Low Vitamin D Status is Associated with Increased Thyrotropin-Receptor Antibody Titer in Graves Disease. Endocr Pract. 2014; 21(3):258-63. DOI: 10.4158/EP14191.OR. View

13.

Skrobot A, Demkow U, Wachowska M . Immunomodulatory Role of Vitamin D: A Review. Adv Exp Med Biol. 2018; 1108:13-23. DOI: 10.1007/5584_2018_246. View

14.

Zhou L, Wang J, Li J, Li T, Chen Y, June R . 1,25-Dihydroxyvitamin D3 Ameliorates Collagen-Induced Arthritis via Suppression of Th17 Cells Through miR-124 Mediated Inhibition of IL-6 Signaling. Front Immunol. 2019; 10:178. PMC: 6374300. DOI: 10.3389/fimmu.2019.00178. View

15.

Kong N, Lan Q, Chen M, Wang J, Shi W, Horwitz D . Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum. 2012; 64(8):2548-58. PMC: 4364395. DOI: 10.1002/art.34513. View

16.

Santinon F, Batignes M, Mebrek M, Biton J, Clavel G, Herve R . Involvement of Tumor Necrosis Factor Receptor Type II in FoxP3 Stability and as a Marker of Treg Cells Specifically Expanded by Anti-Tumor Necrosis Factor Treatments in Rheumatoid Arthritis. Arthritis Rheumatol. 2019; 72(4):576-587. DOI: 10.1002/art.41134. View

17.

Bouchemal M, Hakem D, Azzouz M, Touil-Boukoffa C, Mezioug D . Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D3. Endocr Metab Immune Disord Drug Targets. 2020; 20(8):1282-1294. DOI: 10.2174/1871530320666200402121917. View

18.

Dankers W, Davelaar N, van Hamburg J, van de Peppel J, Colin E, Lubberts E . Human Memory Th17 Cell Populations Change Into Anti-inflammatory Cells With Regulatory Capacity Upon Exposure to Active Vitamin D. Front Immunol. 2019; 10:1504. PMC: 6651215. DOI: 10.3389/fimmu.2019.01504. View

19.

Yang S, Wang J, Brand D, Zheng S . Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications. Front Immunol. 2018; 9:784. PMC: 5916970. DOI: 10.3389/fimmu.2018.00784. View

20.

Ahn H, Chung Y, Cho B . Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence. Medicine (Baltimore). 2017; 96(31):e7700. PMC: 5626158. DOI: 10.1097/MD.0000000000007700. View