PI3 Kinase Signaling Pathway in Hematopoietic Cancers: A Glance in MiRNA's Role

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2021 Mar 6

PMID 33675064

Citations 9

Authors

Elham Roshandel

Leila Noorazar

Behrouz Farhadihosseinabadi

Mahshid Mehdizadeh

Mohammad Hossein Kazemi

Sayeh Parkhideh

Affiliations

Soon will be listed here.

Abstract

Hematopoietic cancers are among the most common malignancies worldwide, which are divided into different types depending on the origin of tumor cells. In recent years, the pivotal role of different signaling pathways in the onset and progression of these cancer types has been well established. One of these pathways, whose role in blood malignancies has been well-defined, is PI3K/mTOR/AKT axis. The signaling pathway involves in a wide variety of important biological events in cells. It is clear that dysregulation of mediators involved in PI3 kinase signaling takes a pivotal role in cancer development. Considering the undeniable role of miRNAs, as one of the well-known families of non-coding RNAs, in gene regulation, we aimed to review the role of miRNAs in regulation of PI3 kinase signaling effectors in hematopoietic cancers.

Citing Articles

The Importance of Phosphoinositide 3-Kinase in Neuroinflammation.

Wright B, King S, Suphioglu C Int J Mol Sci. 2024; 25(21).

PMID: 39519189 PMC: 11546674. DOI: 10.3390/ijms252111638.

The Progress and Prospects of Immune Cell Therapy for the Treatment of Cancer.

Han J, Zhang B, Zheng S, Jiang Y, Zhang X, Mao K Cell Transplant. 2024; 33:9636897241231892.

PMID: 38433349 PMC: 10913519. DOI: 10.1177/09636897241231892.

A Network Comprised of miR-15b and miR-29a Is Involved in Vascular Endothelial Growth Factor Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects.

Gentile A, Lhamyani S, Mengual Mesa M, Pavon-Moron F, Pearson J, Salas J Int J Mol Sci. 2023; 24(19).

PMID: 37833902 PMC: 10572810. DOI: 10.3390/ijms241914456.

Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?.

Kazemi M, Sadri M, Najafi A, Rahimi A, Baghernejadan Z, Khorramdelazad H Front Immunol. 2022; 13:1018962.

PMID: 36389779 PMC: 9651159. DOI: 10.3389/fimmu.2022.1018962.

Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells.

Al-Rawashde F, Al-Wajeeh A, Vishkaei M, Saad H, Johan M, Taib W Pharmaceuticals (Basel). 2022; 15(9).

PMID: 36145344 PMC: 9504933. DOI: 10.3390/ph15091123.

References

OBrien J, Hayder H, Zayed Y, Peng C . Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front Endocrinol (Lausanne). 2018; 9:402. PMC: 6085463. DOI: 10.3389/fendo.2018.00402. View

Burger J, Chiorazzi N . B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol. 2013; 34(12):592-601. PMC: 3898793. DOI: 10.1016/j.it.2013.07.002. View

Gu D, Jiang M, Mei Z, Dai J, Dai C, Fang C . microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. Cancer Lett. 2017; 400:69-78. DOI: 10.1016/j.canlet.2017.04.020. View

Jafari A, Rezaei-Tavirani M, Farhadihosseinabadi B, Taranejoo S, Zali H . HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy. Cancer Invest. 2020; 38(5):310-328. DOI: 10.1080/07357907.2020.1752227. View

Fresno Vara J, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M . PI3K/Akt signalling pathway and cancer. Cancer Treat Rev. 2004; 30(2):193-204. DOI: 10.1016/j.ctrv.2003.07.007. View

Ong P, Wang L, Dai X, Tseng S, Loo S, Sethi G . Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives. Front Pharmacol. 2016; 7:395. PMC: 5079084. DOI: 10.3389/fphar.2016.00395. View

Ghasemi K, Parkhideh S, Kazemi M, Salimi M, Salari S, Nalini R . The role of serum uric acid in the prediction of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. J Clin Lab Anal. 2020; 34(7):e23271. PMC: 7370721. DOI: 10.1002/jcla.23271. View

Orom U, Nielsen F, Lund A . MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell. 2008; 30(4):460-71. DOI: 10.1016/j.molcel.2008.05.001. View

Amodio N, Di Martino M, Foresta U, Leone E, Lionetti M, Leotta M . miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Dis. 2012; 3:e436. PMC: 3542610. DOI: 10.1038/cddis.2012.175. View

10.

Cimmino A, Calin G, Fabbri M, Iorio M, Ferracin M, Shimizu M . miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005; 102(39):13944-9. PMC: 1236577. DOI: 10.1073/pnas.0506654102. View

11.

Hajifathali A, Parkhideh S, Kazemi M, Chegeni R, Roshandel E, Gholizadeh M . Immune checkpoints in hematologic malignancies: What made the immune cells and clinicians exhausted!. J Cell Physiol. 2020; 235(12):9080-9097. DOI: 10.1002/jcp.29769. View

12.

Chiorazzi N, Rai K, Ferrarini M . Chronic lymphocytic leukemia. N Engl J Med. 2005; 352(8):804-15. DOI: 10.1056/NEJMra041720. View

13.

Caligaris-Cappio F, Bertilaccio M, Scielzo C . How the microenvironment wires the natural history of chronic lymphocytic leukemia. Semin Cancer Biol. 2013; 24:43-8. DOI: 10.1016/j.semcancer.2013.06.010. View

14.

Ipsaro J, Joshua-Tor L . From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol. 2015; 22(1):20-8. PMC: 4450863. DOI: 10.1038/nsmb.2931. View

15.

Anderson K, Carrasco R . Pathogenesis of myeloma. Annu Rev Pathol. 2011; 6:249-74. DOI: 10.1146/annurev-pathol-011110-130249. View

16.

Hong B, Ryu H, Kim N, Kim J, Lee E, Moon H . Tumor Suppressor miRNA-204-5p Regulates Growth, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer. Cancer Res. 2019; 79(7):1520-1534. DOI: 10.1158/0008-5472.CAN-18-0891. View

17.

Zou Z, Zhang R, Fan L, Wang L, Fang C, Zhang L . Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. Leuk Lymphoma. 2012; 54(6):1159-64. DOI: 10.3109/10428194.2012.733880. View

18.

Yates L, Norbury C, Gilbert R . The long and short of microRNA. Cell. 2013; 153(3):516-9. DOI: 10.1016/j.cell.2013.04.003. View

19.

Stojic L, Lun A, Mascalchi P, Ernst C, Redmond A, Mangei J . A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun. 2020; 11(1):1851. PMC: 7160116. DOI: 10.1038/s41467-020-14978-7. View

20.

Roodman G . Mechanisms of bone metastasis. N Engl J Med. 2004; 350(16):1655-64. DOI: 10.1056/NEJMra030831. View