Spontaneous Intestinal Perforation in Premature Infants: a National Study

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2021 Mar 6

PMID 33674711

Citations 13

Authors

Marwa M Elgendy

Hasan F Othman

Farah Heis

Ibrahim Qattea

Hany Aly

Affiliations

Soon will be listed here.

Abstract

Objectives: To assess the prevalence and outcomes of spontaneous intestinal perforation (SIP) in very low birth weight infants.

Study Design: This cross-sectional study utilized the National Inpatient Sample dataset for the years 2002-2017. All premature infants with birth weight (BW) <1500 g and with gestational age (GA) ≤32 weeks were included. Analyses were repeated after stratifying the population into two BW sub-categories <1000 g and 1000-1499 g. Trend analysis was done using Cochran-Armitage test. Regression analysis was conducted to control for gestational age, race, and sex.

Result: A total of 658,001 infants were included. SIP (n = 10,443, 1.6%) was mostly (81.9%) in the category <1000 g with 89.9% ≤28 weeks of gestation. There was a significant trend for increased SIP over the years (p < 0.001). SIP was associated with increased mortality (aOR = 2.24, CI: 2.04-2.46, p < 0.001).

Conclusion: After controlling for gestational age and other confounders, SIP is associated with increased mortality in premature infants.

Citing Articles

Retrospective bi-centric observational study comparing primary anastomosis or suturing vs enterostomy for spontaneous intestinal perforations in extremely preterm infants.

Genet E, Gounfle E, Bonnard A, Jaby O, Wang X, Jung C Eur J Pediatr. 2025; 184(3):215.

PMID: 40019632 DOI: 10.1007/s00431-025-06043-6.

The Association Between Perinatal Pharmacologic Treatments and Spontaneous Intestinal Perforation in Extremely Preterm Infants: A Propensity Score Matching Study.

Cheng W, Tu L, Chiang M, Chen Y, Wu W, Hsu K Children (Basel). 2025; 12(2).

PMID: 40003244 PMC: 11854389. DOI: 10.3390/children12020142.

Necrotizing enterocolitis following spontaneous intestinal perforation in very low birth weight neonates.

Dantes G, Keane O, Raikot S, Do L, Rumbika S, He Z J Perinatol. 2024; .

PMID: 39448869 DOI: 10.1038/s41372-024-02155-3.

Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification.

Hapnes N, Stensvold H, Bjornland K, Saeter T, Guthe H, Stoen R BMJ Paediatr Open. 2024; 8(1).

PMID: 39299770 PMC: 11418550. DOI: 10.1136/bmjpo-2024-002722.

Initial surgery for spontaneous intestinal perforation in extremely low birth weight infants is not associated with mortality or in-hospital morbidities.

Hair A, Sullivan K, Ahmad I, Zaniletti I, Acker S, Premkumar M J Perinatol. 2024; 44(12):1746-1754.

PMID: 38992239 DOI: 10.1038/s41372-024-02037-8.