Tissue Engineering: Relevance to Neonatal Congenital Heart Disease

Overview

Journal Semin Fetal Neonatal Med

Publisher Elsevier

Specialties Gynecology & Obstetrics
Pediatrics

Date 2021 Mar 6

PMID 33674254

Citations 7

Authors

Kevin M Blum

Gabriel J M Mirhaidari

Christopher K Breuer

Affiliations

Soon will be listed here.

Abstract

Congenital heart disease (CHD) represents a large clinical burden, representing the most common cause of birth defect-related death in the newborn. The mainstay of treatment for CHD remains palliative surgery using prosthetic vascular grafts and valves. These devices have limited effectiveness in pediatric patients due to thrombosis, infection, limited endothelialization, and a lack of growth potential. Tissue engineering has shown promise in providing new solutions for pediatric CHD patients through the development of tissue engineered vascular grafts, heart patches, and heart valves. In this review, we examine the current surgical treatments for congenital heart disease and the research being conducted to create tissue engineered products for these patients. While much research remains to be done before tissue engineering becomes a mainstay of clinical treatment for CHD patients, developments have been progressing rapidly towards translation of tissue engineering devices to the clinic.

Citing Articles

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