Worms, Fat, and Death: Lipid Metabolites Regulate Cell Death

Overview

Journal Metabolites

Publisher MDPI

Date 2021 Mar 6

PMID 33672292

Citations 6

Authors

Marcos A Perez

Jennifer L Watts

Affiliations

Soon will be listed here.

Abstract

is well-known as the model organism used to elucidate the genetic pathways underlying the first described form of regulated cell death, apoptosis. Since then, investigations have contributed to the further understanding of lipids in apoptosis, especially the roles of phosphatidylserines and phosphatidylinositols. More recently, studies in have shown that dietary polyunsaturated fatty acids can induce the non-apoptotic, iron-dependent form of cell death, ferroptosis. In this review, we examine the roles of various lipids in specific aspects of regulated cell death, emphasizing recent work in .

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