-From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Mar 6

PMID 33669808

Citations 2

Authors

Elvira Forte

Micheal A McLellan

Daniel A Skelly

Nadia A Rosenthal

Affiliations

Soon will be listed here.

Abstract

Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.

Citing Articles

Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics.

Palmer J, Rosenthal N, Teichmann S, Litvinukova M Circ Res. 2024; 134(12):1681-1702.

PMID: 38843288 PMC: 11149945. DOI: 10.1161/CIRCRESAHA.124.323672.

Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention.

Yin X, Yin X, Pan X, Zhang J, Fan X, Li J Front Pharmacol. 2023; 14:1070973.

PMID: 37056987 PMC: 10086160. DOI: 10.3389/fphar.2023.1070973.

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