A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Mar 6

PMID 33668793

Citations 4

Authors

Gennady Khvorykh

Andrey Khrunin

Ivan Filippenkov

Vasily Stavchansky

Lyudmila Dergunova

Svetlana Limborska

Affiliations

Soon will be listed here.

Abstract

In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well.

Citing Articles

The Study of the Association of Polymorphisms in , , , , , and Genes with the Risk and Outcome of Ischemic Stroke in the Russian Population.

Khrunin A, Khvorykh G, Arapova A, Kulinskaya A, Koltsova E, Petrova E Int J Mol Sci. 2023; 24(7).

PMID: 37047799 PMC: 10095190. DOI: 10.3390/ijms24076831.

Special Issue: "Genomics of Stroke".

Limborska S, Filippenkov I Genes (Basel). 2022; 13(3).

PMID: 35327969 PMC: 8955494. DOI: 10.3390/genes13030415.

Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study.

Khrunin A, Khvorykh G, Rozhkova A, Koltsova E, Petrova E, Kimelfeld E Genes (Basel). 2021; 12(12).

PMID: 34946887 PMC: 8701352. DOI: 10.3390/genes12121938.

Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia-Reperfusion.

Filippenkov I, Stavchansky V, Denisova A, Valieva L, Remizova J, Mozgovoy I Genes (Basel). 2021; 12(12).

PMID: 34946819 PMC: 8701796. DOI: 10.3390/genes12121870.

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