Exercise Training and Burdock Root (Arctium Lappa L.) Extract Independently Improve Abdominal Obesity and Sex Hormones in Elderly Women with Metabolic Syndrome

Overview

Journal Sci Rep

Specialty Science

Date 2021 Mar 5

PMID 33664334

Citations 4

Authors

Min-Seong Ha

Jang Soo Yook

Minchul Lee

Kazuya Suwabe

Woo-Min Jeong

Jae-Jun Kwak

Hideaki Soya

Affiliations

Soon will be listed here.

Abstract

The prevalence of metabolic syndrome (MS) is increasing among the elderly, and new lifestyle-based treatment strategies are warranted. We conducted a randomized, double-blind controlled trial of the effects of aquatic exercise (AE) and/or consumption of burdock root extract (BE) on body composition and serum sex hormones, i.e., testosterone, estradiol, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone-sulfate (DHEA-S) in elderly women with MS. The percentage of abdominal fat was decreased in the AE group. Waist circumference was increased in the control (CON) group, but not in the other groups. SHBG and estradiol levels were enhanced by both AE and BE and correlated with changes in fat-related body composition. DHEA-S levels only increased in the BE group, which was consistent with changes in lean body mass. Testosterone levels decreased in the CON group, which correlated with changes in lean body mass, skeletal muscle mass, body fat, and waist circumference. Our findings suggested that the combined AE/BE intervention exerted no synergistic and/or additive effects on any sex-related outcome measures in elderly women with MS.

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References

Butler J, Rodondi N, Zhu Y, Figaro K, Fazio S, Vaughan D . Metabolic syndrome and the risk of cardiovascular disease in older adults. J Am Coll Cardiol. 2006; 47(8):1595-602. DOI: 10.1016/j.jacc.2005.12.046. View

Ginsberg H, Maccallum P . The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus. J Cardiometab Syndr. 2009; 4(2):113-9. PMC: 2901596. DOI: 10.1111/j.1559-4572.2008.00044.x. View

Ford E, Giles W, Dietz W . Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287(3):356-9. DOI: 10.1001/jama.287.3.356. View

Saad M, Cardoso G, Martins W, Velarde L, da Cruz Filho R . Prevalence of metabolic syndrome in elderly and agreement among four diagnostic criteria. Arq Bras Cardiol. 2014; 102(3):263-9. PMC: 3987322. DOI: 10.5935/abc.20140013. View

Labrie F, Luu-The V, Labrie C, Simard J . DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol. 2001; 22(3):185-212. DOI: 10.1006/frne.2001.0216. View

Barrett-Connor E, Ferrara A . Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study. J Clin Endocrinol Metab. 1996; 81(1):59-64. DOI: 10.1210/jcem.81.1.8550794. View

Weinberg M, Manson J, Buring J, Cook N, Seely E, Ridker P . Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women. Metabolism. 2006; 55(11):1473-80. PMC: 1633722. DOI: 10.1016/j.metabol.2006.06.017. View

Ostman C, Smart N, Morcos D, Duller A, Ridley W, Jewiss D . The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis. Cardiovasc Diabetol. 2017; 16(1):110. PMC: 5577843. DOI: 10.1186/s12933-017-0590-y. View

Ennour-Idrissi K, Maunsell E, Diorio C . Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials. Breast Cancer Res. 2015; 17(1):139. PMC: 4635995. DOI: 10.1186/s13058-015-0647-3. View

10.

Copeland J, Consitt L, Tremblay M . Hormonal responses to endurance and resistance exercise in females aged 19-69 years. J Gerontol A Biol Sci Med Sci. 2002; 57(4):B158-65. DOI: 10.1093/gerona/57.4.b158. View

11.

Kim J, Kim D . Effects of aerobic exercise training on serum sex hormone binding globulin, body fat index, and metabolic syndrome factors in obese postmenopausal women. Metab Syndr Relat Disord. 2012; 10(6):452-7. DOI: 10.1089/met.2012.0036. View

12.

Ha M, Kim J, Ha S, Kim Y, Kim D . Positive influence of aqua exercise and burdock extract intake on fitness factors and vascular regulation substances in elderly. J Clin Biochem Nutr. 2019; 64(1):73-78. PMC: 6348416. DOI: 10.3164/jcbn.18-60. View

13.

Anderssen S, Carroll S, Urdal P, Holme I . Combined diet and exercise intervention reverses the metabolic syndrome in middle-aged males: results from the Oslo Diet and Exercise Study. Scand J Med Sci Sports. 2007; 17(6):687-95. DOI: 10.1111/j.1600-0838.2006.00631.x. View

14.

Ferracane R, Graziani G, Gallo M, Fogliano V, Ritieni A . Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. J Pharm Biomed Anal. 2009; 51(2):399-404. DOI: 10.1016/j.jpba.2009.03.018. View

15.

Ahangarpour A, Heidari H, Oroojan A, Mirzavandi F, Nasr Esfehani K, Mohammadi Z . Antidiabetic, hypolipidemic and hepatoprotective effects of root's hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice. Avicenna J Phytomed. 2017; 7(2):169-179. PMC: 5355822. View

16.

Annunziata G, Barrea L, Ciampaglia R, Cicala C, Arnone A, Savastano S . Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal-based studies. Phytother Res. 2019; 33(9):2213-2220. DOI: 10.1002/ptr.6416. View

17.

Min B, Lee H, Song J, Joo Han M, Chung J . Arctiin inhibits adipogenesis in 3T3-L1 cells and decreases adiposity and body weight in mice fed a high-fat diet. Nutr Res Pract. 2014; 8(6):655-61. PMC: 4252525. DOI: 10.4162/nrp.2014.8.6.655. View

18.

Ha M, Kim J, Kim Y, Kim D . Effects of aquarobic exercise and burdock intake on serum blood lipids and vascular elasticity in Korean elderly women. Exp Gerontol. 2017; 101:63-68. DOI: 10.1016/j.exger.2017.11.005. View

19.

Xu T, Liu J, Liu J, Zhu G, Han S . Relation between metabolic syndrome and body compositions among Chinese adolescents and adults from a large-scale population survey. BMC Public Health. 2017; 17(1):337. PMC: 5397692. DOI: 10.1186/s12889-017-4238-3. View

20.

Farinha J, Steckling F, Stefanello S, Sangoi Cardoso M, Nunes L, Barcelos R . Response of oxidative stress and inflammatory biomarkers to a 12-week aerobic exercise training in women with metabolic syndrome. Sports Med Open. 2015; 1(1):19. PMC: 5005613. DOI: 10.1186/s40798-015-0011-2. View