Visit-to-visit Variability of Serum Uric Acid Measurements and the Risk of All-cause Mortality in the General Population

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2021 Mar 5

PMID 33663587

Citations 6

Authors

Xue Tian

Anxin Wang

Yingting Zuo

Shuohua Chen

Licheng Zhang

Shouling Wu

Yanxia Luo

Affiliations

Soon will be listed here.

Abstract

Background: Evidence on longitudinal variability of serum uric acid (SUA) and risk of all-cause mortality in the general population is limited, as many prior studies focused on a single measurement of SUA.

Methods: A total of 53,956 participants in the Kailuan study who underwent three health examinations during 2006 to 2010 were enrolled. Variability of SUA was measured using the coefficient of variation (primary index), standard deviation, average real variability, and variability independent of the mean. Cox proportional hazard regressions were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the association of variability of SUA with subsequent risk of all-cause mortality, considering its magnitude and the direction and across different baseline SUA categories.

Results: Over a median follow-up of 7.04 years, 2728 participants died. The highest variability of SUA was associated with an increased risk of all-cause mortality, the HR was 1.33 (95% CI, 1.20-1.49) compared with the lowest variability. In this group, both a large fall (HR, 1.28; 95% CI, 1.14-1.44) and rise (HR, 1.18; 95% 1.05-1.32) in SUA were related to risk of all-cause mortality. These associations were similar across different baseline SUA categories. Consistent results were observed in alternative measures of SUA variability. Moreover, individuals with higher variability in SUA were more related to common risk factors than those with stable SUA.

Conclusions: Higher variability in SUA was independently associated with the risk of all-cause mortality irrespective of baseline SUA and direction of variability in the general population.

Citing Articles

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Park H, Chang Y, Lee H, Hong I, Song T PLoS One. 2023; 18(8):e0289743.

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Association of gamma-glutamyl transferase variability with risk of osteoporotic fractures: A nationwide cohort study.

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Association of gamma-glutamyl transferase variability with risk of venous thrombosis.

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Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons.

Kawamoto R, Kikuchi A, Ninomiya D, Kumagi T Int J Anal Chem. 2023; 2023:7382320.

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