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The Effect of Food on the Systemic Availability of Ketoprofen

Overview
Journal Eur J Clin Pharmacol
Specialty Pharmacology
Date 1988 Jan 1
PMID 3366169
Citations 9
Authors
B Bannwarth
F Lapicque
P Netter
C Monot
J N Tamisier
P Thomas
R J Royer
Affiliations
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Abstract

We have studied the pharmacokinetics of ketoprofen, a non-steroidal anti-inflammatory drug, in 12 patients after a single 100 mg oral dose both in fasting conditions and with a meal. Food significantly affected the peak plasma concentration of ketoprofen and decreased its absorption rate. However, the extent of absorption of ketoprofen, as reflected by the area under the plasma concentration time curve, appeared to be unchanged in the presence of food.

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