Is REM Sleep Behavior Disorder a Friend or Foe of Obstructive Sleep Apnea? Clinical and Etiological Implications for Neurodegeneration

Overview

Journal J Clin Sleep Med

Specialties Neurology
Psychiatry

Date 2021 Mar 4

PMID 33660615

Citations 3

Authors

Yu Jin Jung

Eungseok Oh

Affiliations

Soon will be listed here.

Abstract

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia characterized by loss of muscle atonia during rapid eye movement sleep, associated with complex motor enactment of dreams. Obstructive sleep apnea (OSA) is a relatively common sleep disorder characterized by repetitive episodes of upper airway obstruction while sleeping, which can result in hypoxemia and sleep fragmentation. Even though the nature of RBD and OSA is different, OSA may sometimes be accompanied by RBD symptoms. Accordingly, it is reasonable to distinguish these 2 sleep disorders in people with dream enactment behaviors. Although RBD and OSA share similar sleep phenomena, their association has yet to be elucidated. Herein we draw attention to various RBD-mimicking conditions, RBD combined with OSA, and the relationship between RBD and OSA. Furthermore, the clinical implications of OSA in neurodegeneration and the optimized management of RBD combined with OSA are also discussed in this review.

Citing Articles

REM sleep obstructive sleep apnoea.

Bonsignore M, Mazzuca E, Baiamonte P, Bouckaert B, Verbeke W, Pevernagie D Eur Respir Rev. 2024; 33(171).

PMID: 38355150 PMC: 10865098. DOI: 10.1183/16000617.0166-2023.

Sleep apnea and autonomic dysfunction in patients with dementia.

Herberts M, Kolla B, Paul T, Mekala P, Mansukhani M Front Neurosci. 2022; 16:951147.

PMID: 36408398 PMC: 9669746. DOI: 10.3389/fnins.2022.951147.

RBD, sexsomnia, sleepwalking, and sleep paralysis comorbidities: relevance to pulmonary, dental, and behavioral sleep medicine.

Schenck C Sleep Sci. 2021; 14(2):87-91.

PMID: 34381571 PMC: 8340893. DOI: 10.5935/1984-0063.20210018.

References

Jessen N, Munk A, Lundgaard I, Nedergaard M . The Glymphatic System: A Beginner's Guide. Neurochem Res. 2015; 40(12):2583-99. PMC: 4636982. DOI: 10.1007/s11064-015-1581-6. View

Cova I, Priori A . Diagnostic biomarkers for Parkinson's disease at a glance: where are we?. J Neural Transm (Vienna). 2018; 125(10):1417-1432. PMC: 6132920. DOI: 10.1007/s00702-018-1910-4. View

Li S, Lam S, Zhang J, Yu M, Chan J, Liu Y . A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder. Sleep Med. 2016; 21:114-20. DOI: 10.1016/j.sleep.2015.12.020. View

Martin-Gallego A, Gonzalez-Garcia L, Carrasco-Brenes A, Segura-Fernandez-Nogueras M, Delgado-Babiano A, Ros-Sanjuan A . Brainstem and Autonomic Nervous System Dysfunction: A Neurosurgical Point of View. Acta Neurochir Suppl. 2017; 124:221-229. DOI: 10.1007/978-3-319-39546-3_34. View

Gottlieb D, Punjabi N . Diagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA. 2020; 323(14):1389-1400. DOI: 10.1001/jama.2020.3514. View

Cohen-Zion M, Stepnowsky C, Johnson S, Marler M, Dimsdale J, Ancoli-Israel S . Cognitive changes and sleep disordered breathing in elderly: differences in race. J Psychosom Res. 2004; 56(5):549-53. DOI: 10.1016/j.jpsychores.2004.02.002. View

Schaefer C, Kunz D, Bes F . Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A Case Series. Curr Alzheimer Res. 2017; 14(10):1084-1089. DOI: 10.2174/1567205014666170523094938. View

Htoo A, Greenberg H, Tongia S, Chen G, Henderson T, Wilson D . Activation of nuclear factor kappaB in obstructive sleep apnea: a pathway leading to systemic inflammation. Sleep Breath. 2006; 10(1):43-50. DOI: 10.1007/s11325-005-0046-6. View

Burns J, Consens F, Little R, Angell K, Gilman S, Chervin R . EMG variance during polysomnography as an assessment for REM sleep behavior disorder. Sleep. 2008; 30(12):1771-8. PMC: 2276138. DOI: 10.1093/sleep/30.12.1771. View

10.

Galbiati A, Verga L, Giora E, Zucconi M, Ferini-Strambi L . The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies. Sleep Med Rev. 2018; 43:37-46. DOI: 10.1016/j.smrv.2018.09.008. View

11.

Frauscher B, Gschliesser V, Brandauer E, Marti I, Furtner M, Ulmer H . REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. Sleep Med. 2009; 11(2):167-71. DOI: 10.1016/j.sleep.2009.03.011. View

12.

Ramesh V, Nair D, Zhang S, Hakim F, Kaushal N, Kayali F . Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway. J Neuroinflammation. 2012; 9:91. PMC: 3411474. DOI: 10.1186/1742-2094-9-91. View

13.

Cochen De Cock V, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M . Is obstructive sleep apnea a problem in Parkinson's disease?. Sleep Med. 2009; 11(3):247-52. DOI: 10.1016/j.sleep.2009.05.008. View

14.

Manaker S, Tischler L . Origin of serotoninergic afferents to the hypoglossal nucleus in the rat. J Comp Neurol. 1993; 334(3):466-76. DOI: 10.1002/cne.903340310. View

15.

Suetsugi M, Mizuki Y, Yamamoto K, Uchida S, Watanabe Y . The effect of placebo administration on the first-night effect in healthy young volunteers. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(4):839-47. DOI: 10.1016/j.pnpbp.2007.01.019. View

16.

St Louis E, Boeve A, Boeve B . REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies. Mov Disord. 2017; 32(5):645-658. DOI: 10.1002/mds.27018. View

17.

Arnulf I, Neutel D, Herlin B, Golmard J, Leu-Semenescu S, Cochen De Cock V . Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease. Sleep. 2015; 38(10):1529-35. PMC: 4576326. DOI: 10.5665/sleep.5040. View

18.

Aurora R, Zak R, Maganti R, Auerbach S, Casey K, Chowdhuri S . Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med. 2010; 6(1):85-95. PMC: 2823283. View

19.

He K, Kapur V . Sleep-Disordered Breathing and Excessive Daytime Sleepiness. Sleep Med Clin. 2017; 12(3):369-382. DOI: 10.1016/j.jsmc.2017.03.010. View

20.

Schenck C, Montplaisir J, Frauscher B, Hogl B, Gagnon J, Postuma R . Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group. Sleep Med. 2013; 14(8):795-806. PMC: 8783206. DOI: 10.1016/j.sleep.2013.02.016. View