Direct Measurement of the Scattering Coefficient

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2021 Mar 4

PMID 33659078

Citations 6

Authors

Martin Hohmann

Benjamin Lengenfelder

Daniel Muhr

Moritz Spath

Maximilian Hauptkorn

Florian Klampfl

Michael Schmidt

Affiliations

Soon will be listed here.

Abstract

In general, the measurement of the main three optical properties ( , and ) in turbid media requires a very precise measurement of the total transmission (TT), the total reflection (TR) and the collimated transmission (CT). Furthermore, an inverse algorithm such as inverse adding doubling or inverse Monte-Carlo-simulations is required for the reconstruction of the optical properties. Despite many available methods, the error free measurement of the scattering coefficient or the g-factor still remains challenging. In this study, we present a way to directly calculate the scattering coefficient from the total and collimated transmission. To allow this, it can be shown that is proportional to for a wide range of optical properties if the sample is thick enough. Moreover, a set-up is developed and validated to measure the collimated transmission precisely.

Citing Articles

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Reconstruction of Optical Properties in Turbid Media: Omitting the Need of the Collimated Transmission for an Integrating Sphere Setup.

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References

Wilson B, Patterson M, Flock S . Indirect versus direct techniques for the measurement of the optical properties of tissues. Photochem Photobiol. 1987; 46(5):601-8. DOI: 10.1111/j.1751-1097.1987.tb04820.x. View

Pickering J, Prahl S, van Wieringen N, Beek J, Sterenborg H, van Gemert M . Double-integrating-sphere system for measuring the optical properties of tissue. Appl Opt. 2010; 32(4):399-410. DOI: 10.1364/AO.32.000399. View

Svensson T, Andersson-Engels S, Einarsdottir M, Svanberg K . In vivo optical characterization of human prostate tissue using near-infrared time-resolved spectroscopy. J Biomed Opt. 2007; 12(1):014022. DOI: 10.1117/1.2435175. View

Jones L, Preyer N, Wolfsen H, Reynolds D, Davis M, Wallace M . Monte carlo model of stricture formation in photodynamic therapy of normal pig esophagus. Photochem Photobiol. 2009; 85(1):341-6. DOI: 10.1111/j.1751-1097.2008.00445.x. View

Chan E, Menovsky T, Welch A . Effects of cryogenic grinding on soft-tissue optical properties. Appl Opt. 2010; 35(22):4526-32. DOI: 10.1364/AO.35.004526. View

Jacques S . Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58(11):R37-61. DOI: 10.1088/0031-9155/58/11/R37. View

Troy T, Page D, Sevick-Muraca E . Optical properties of normal and diseased breast tissues: prognosis for optical mammography. J Biomed Opt. 2012; 1(3):342-55. DOI: 10.1117/12.239905. View

Fukutomi D, Ishii K, Awazu K . Highly accurate scattering spectra of strongly absorbing samples obtained using an integrating sphere system by considering the angular distribution of diffusely reflected light. Lasers Med Sci. 2015; 30(4):1335-40. DOI: 10.1007/s10103-015-1734-5. View

Cerussi A, Tanamai V, Hsiang D, Butler J, Mehta R, Tromberg B . Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy. Philos Trans A Math Phys Eng Sci. 2011; 369(1955):4512-30. PMC: 3263790. DOI: 10.1098/rsta.2011.0279. View

10.

Fantini S, Walker S, Franceschini M, Kaschke M, Schlag P, Moesta K . Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods. Appl Opt. 2008; 37(10):1982-9. DOI: 10.1364/ao.37.001982. View

11.

Kienle A, Forster F, Hibst R . Influence of the phase function on determination of the optical properties of biological tissue by spatially resolved reflectance. Opt Lett. 2007; 26(20):1571-3. DOI: 10.1364/ol.26.001571. View

12.

Yaroslavsky A, Yaroslavsky I, Goldbach T, Schwarzmaier H . Influence of the scattering phase function approximation on the optical properties of blood determined from the integrating sphere measurements. J Biomed Opt. 2012; 4(1):47-53. DOI: 10.1117/1.429920. View

13.

Spinelli L, Botwicz M, Zolek N, Kacprzak M, Milej D, Sawosz P . Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink. Biomed Opt Express. 2014; 5(7):2037-53. PMC: 4102347. DOI: 10.1364/BOE.5.002037. View

14.

Doornbos R, Lang R, Aalders M, Cross F, Sterenborg H . The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy. Phys Med Biol. 1999; 44(4):967-81. DOI: 10.1088/0031-9155/44/4/012. View

15.

Kienle A, Lilge L, Patterson M, Hibst R, Steiner R, Wilson B . Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue. Appl Opt. 2010; 35(13):2304-14. DOI: 10.1364/AO.35.002304. View

16.

Hohmann M, Lengenfelder B, Kanawade R, Klampfl F, Douplik A, Albrecht H . Measurement of optical properties of pig esophagus by using a modified spectrometer set-up. J Biophotonics. 2017; 11(1). DOI: 10.1002/jbio.201600187. View

17.

Yu L, Nina-Paravecino F, Kaeli D, Fang Q . Scalable and massively parallel Monte Carlo photon transport simulations for heterogeneous computing platforms. J Biomed Opt. 2018; 23(1):1-4. PMC: 5785911. DOI: 10.1117/1.JBO.23.1.010504. View

18.

Zonios G, Perelman L, Backman V, Manoharan R, Fitzmaurice M, van Dam J . Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo. Appl Opt. 2008; 38(31):6628-37. DOI: 10.1364/ao.38.006628. View

19.

Mourant J, Boyer J, Hielscher A, Bigio I . Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separations. Opt Lett. 2009; 21(7):546-8. DOI: 10.1364/ol.21.000546. View

20.

Wang L, Jacques S . Error estimation of measuring total interaction coefficients of turbid media using collimated light transmission. Phys Med Biol. 1994; 39(12):2349-54. DOI: 10.1088/0031-9155/39/12/015. View