Stress-induced Occupancy and Translocation of Hippocampal Glucocorticoid Receptors

Overview

Journal Brain Res

Specialty Neurology

Date 1988 Mar 29

PMID 3365557

Citations 12

Authors

M J Meaney

V Viau

D H Aitken

S Bhatnagar

Affiliations

Soon will be listed here.

Abstract

Using an exchange assay for glucocorticoid receptors, we found that immobilization stress resulted in a approximately 50% translocation of receptors (i.e. receptors assumed to be chromatin bound) from soluble fractions prepared from hippocampal tissue. The increased hormone-receptor signal persisted for about 2-4 h following the termination of the stressor. This time course is consistent with the known temporal pattern for the negative feedback of glucocorticoids on adrenocortical activity.

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